PMID: 3753724Feb 1, 1986Paper

Bleeding time in hemophilia A: potential mechanisms for prolongation

The Journal of Pediatrics
M J StuartJ Gauldie

Abstract

Prolongation of bleeding time has been previously observed in hemophilia, although no cause has been elucidated. We measured bleeding time, platelet aggregation, nucleotide release, and thromboxane B2 (TXB2), plasma 6-keto-PGF 1 alpha, platelet-associated IgG (PAIgG), and circulating immune complexes in 31 unselected patients with severe hemophilia A and in 17 controls. In 85% of patients with hemophilia A, the bleeding time was greater than 2 SD above the control level (greater than 8 minutes). Sixty-six percent of patients with hemophilia A had circulating immune complexes, and there was a striking relationship between the presence of these complexes and prolonged bleeding time. Plasma 6-keto-PGF 1 alpha levels were significantly elevated in the patient group, and correlated with bleeding time changes. Platelet aggregation and nucleotide release were normal in the patients with hemophilia, although reduced platelet TXB2 biosynthesis was noted in 26%. No correlation was demonstrated between bleeding time and impairment of platelet TXB2 formation. Seventy-two percent of the patients with hemophilia A had elevated levels of PAIgG, and an inverse relationship between PAIgG and platelet count was observed. No relationship was note...Continue Reading

References

Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
Nov 1, 1979·Journal of Clinical Pathology·S L CohenJ Burton-Kee
Jun 19, 1975·The New England Journal of Medicine·P L Pevine
Jun 1, 1985·The Journal of Pediatrics·M J StuartS Boone
Mar 1, 1974·American Journal of Diseases of Children·R A BinderH Mielke
Mar 1, 1984·The Journal of Clinical Investigation·D B CinesR J DeHoratius
May 1, 1980·Prostaglandins and Medicine·L C Poleshuck, H R Strausser

❮ Previous
Next ❯

Citations

Jan 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A BeitzC Giessler
Aug 1, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jae C Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.