BleeMACS: rationale and design of the study

Journal of Cardiovascular Medicine
Fabrizio D'AscenzoSasko Kedev

Abstract

Bleeding events after an acute coronary syndrome have a negative impact on prognosis. Available risk scores are limited by suboptimal accuracy, prediction of only in-hospital events and absence of patients treated with new antiplatelet agents in the current era of widespread use of percutaneous coronary intervention. The BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) project is a multicenter investigator-initiated international retrospective registry that enrolled more than 15 000 patients discharged with a definitive diagnosis of acute coronary syndrome and treated with percutaneous revascularization. The primary end point is the incidence of major bleeding events requiring hospitalization and/or red cell transfusion concentrates within 1 year. An integer risk score for bleeding within the first year after hospital discharge will be developed from a multivariate competing-risks regression. The BleeMACS registry collaborative will allow development and validation of a risk score for prediction of major bleeding during follow-up for patients receiving contemporary therapies for acute coronary syndrome.

References

Sep 2, 1993·The New England Journal of Medicine·UNKNOWN GUSTO investigators
Dec 22, 1999·International Journal of Epidemiology·P RoystonW Sauerbrei
Jun 16, 2005·JAMA : the Journal of the American Medical Association·Shamir R MehtaSalim Yusuf
Sep 19, 2006·Journal of Clinical Epidemiology·A Rogier T DondersKarel G M Moons
Nov 6, 2007·The New England Journal of Medicine·Stephen D WiviottUNKNOWN TRITON-TIMI 38 Investigators
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jun 2, 2010·Journal of the American College of Cardiology·Roxana MehranGregg W Stone
Sep 26, 2013·European Heart Journal. Acute Cardiovascular Care·Emad Abu-AssiJosé Ramón González-Juanatey
Dec 3, 2014·International Journal of Cardiology·Claudio MorettiFiorenzo Gaita
Jan 17, 2015·The American Journal of Cardiology·Sergio Raposeiras RoubínJosé Ramón González Juanatey
May 4, 2015·Emergency Medicine Journal : EMJ·Claudio MorettiFiorenzo Gaita
Jun 9, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Sergio Raposeiras-RoubínJosé Ramón González-Juanatey

❮ Previous
Next ❯

Citations

Jun 13, 2018·Journal of Cardiovascular Medicine·Carlo Di MarioFrancesco Rossi
Oct 6, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mattia PeyracchiaFabrizio D'Ascenzo
Oct 16, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Mario IannacconeSasko Kedev

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02466854

Software Mentioned

BleeMACS
R
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.