Bleomycin-induced life prolongation of mice infected with Trypanosoma brucei brucei EATRO 110

Transactions of the Royal Society of Tropical Medicine and Hygiene
H C NathanS H Hutner

Abstract

The antitumour antibiotic bleomycin, supplied as commercial BlenoxaneR (a mixture of bleomycinic acids), at 7 or 14 mg/kg prolonged life greater than 30 days beyond death of controls without relapse or sign of trypanosomes in the peripheral blood of mice infected with Trypanosoma b. brucei EATRO 110. Control mice died in three to four days. The purified A2 and B2 bleomycin congeners were also active at this dose. Spermidine, spermine and hirudonine (1,8-diamidinospermidine) but not putrescine, co-administered with drug, annulled the curative effects of these compounds, as signalled by appearance of trypanosomes in the blood and death of the animals.

References

Feb 1, 1979·The Laryngoscope·R C BoneS L Seagren
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N J OppenheimerS M Hecht
Dec 14, 1979·Biochemical and Biophysical Research Communications·J C DabrowiakS T Crooke
Jan 1, 1979·Zeitschrift für allgemeine Mikrobiologie·D ScholzH A Rosenthal
Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Williamson
Feb 1, 1979·Antimicrobial Agents and Chemotherapy·K E KinnamonD S Rane
Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Hassan-KingE M Sutcliffe
May 1, 1978·Antimicrobial Agents and Chemotherapy·J Williamson, T J Scott-Finnigan
Jul 20, 1978·Nature·S S Cohen
Jul 1, 1975·Nucleic Acids Research·T T SakaiS S Cohen

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Citations

Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A B ClarksonA Sjoerdsma
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T A Shapiro, P T Englund

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