Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns

Chemico-biological Interactions
R S LloydC W Haidle

Abstract

Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S LloydD L Robberson
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D E Depew, J C Wang
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D E PulleyblankH P Vosberg
Nov 28, 1971·Journal of Molecular Biology·H B GrayJ Vinograd

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