Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival.

The Journal of Experimental Medicine
Gislâine A MartinsKathryn Calame

Abstract

Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp-1 in T cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repression of Fos transcription. Using these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled. This activity of Blimp-1 is important for cytokine deprivation-induced T cell death and for attenuating T cell proliferation in antigen-specific responses both in vitro and in vivo.

References

Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J W Mier, R C Gallo
Jun 1, 1995·Current Opinion in Immunology·J JainA Rao
Mar 1, 1994·Molecular and Cellular Biology·J JainA Rao
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Oct 14, 2000·Archives of Environmental Contamination and Toxicology·S M Macfie, P M Welbourn
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A YuiE V Rothenberg
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Mar 17, 2004·Journal of Clinical Immunology·B Martinez-MariñoJ A Levy
Oct 2, 2004·Current Biology : CB·Sudipto Roy, Teclise Ng
Jan 6, 2005·Science's STKE : Signal Transduction Knowledge Environment·Jun O Liu
Apr 15, 2005·Molecular Immunology·Kristen JohnsonKathryn Calame
Jun 7, 2005·Nature·Yasuhide OhinataM Azim Surani
Nov 30, 2005·The Journal of Experimental Medicine·Miriam Shapiro-ShelefKathryn Calame
Mar 28, 2006·Nature Immunology·Axel KalliesStephen L Nutt
Mar 28, 2006·Nature Immunology·Gislâine A MartinsKathryn Calame
Apr 18, 2006·Current Opinion in Immunology·R Lee ReinhardtRichard M Locksley
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dapeng Gong, Thomas R Malek
Jan 18, 2007·The Journal of Experimental Medicine·Alejandro V VillarinoChristopher A Hunter
Sep 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Erna MagnúsdóttirKathryn Calame
Dec 8, 2007·Annual Review of Immunology·Thomas R Malek
Mar 29, 2008·Annual Review of Immunology·Gislâine Martins, Kathryn Calame

❮ Previous
Next ❯

Citations

Sep 6, 2012·Immunologic Research·Lindsay E EdwardsRoss M Kedl
Jan 20, 2010·Nature Immunology·Shane CrottyStephen P Schoenberger
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chunyang LienPaula M Pitha
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hélène DecaluweJames P Di Santo
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Can KüçükWing C Chan
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ming-Feng ChiangKuo-I Lin
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hsiao-Wei TsaoI-Cheng Ho
Apr 28, 2010·Nucleic Acids Research·Gina M DoodyReuben M Tooze
Jun 27, 2012·Molecular and Cellular Biology·Marc A J MorganElizabeth K Bikoff
Apr 10, 2010·Journal of Biomedicine & Biotechnology·Maureen A Cox, Allan J Zajac
May 24, 2011·Clinical & Developmental Immunology·Gerard F Hoyne
Jan 10, 2013·The Journal of Clinical Investigation·Sun Jung KimBetty Diamond
May 4, 2013·Immunotherapy·Roza NurievaAnupama Sahoo
Jun 21, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Oxana V Klimenko
Feb 15, 2013·European Journal of Immunology·James E Thaventhiran, Douglas T Fearon
Mar 29, 2011·European Journal of Cell Biology·Erwin Hans DuitmanSilvia Bulfone-Paus
Jul 14, 2009·Current Opinion in Genetics & Development·Elizabeth K BikoffElizabeth J Robertson
Mar 10, 2009·Seminars in Immunology·Louise M D'CruzAnanda W Goldrath
Dec 17, 2008·Experimental Cell Research·Shinu A John, Lee Ann Garrett-Sinha
Jan 22, 2011·Annals of the New York Academy of Sciences·Carmen GerlachTon N M Schumacher
Apr 15, 2011·Immunological Reviews·Roza I NurievaChen Dong
May 16, 2012·European Journal of Immunology·Stefanie ThieleAndreas Pahl
Jul 20, 2010·Immunological Reviews·Jill M Angelosanto, E John Wherry
Apr 14, 2015·European Journal of Immunology·Tiago AmadoAnita Q Gomes
Jan 15, 2015·Immunology and Cell Biology·Frann Antignano, Colby Zaph
Dec 19, 2013·PloS One·Bernard Ycart
Mar 19, 2014·Mathematical Biosciences·H AyoubR Thiébaut
Aug 3, 2016·The Journal of Experimental Medicine·SuJin HwangImtiaz A Khan
Oct 14, 2016·Current Rheumatology Reports·Masayuki Mizui, George C Tsokos

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
immunoprecipitation
ChIP
PMA
transgenic

Software Mentioned

Primer
rVista

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.