BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Katerina VrzalikovaPaul G Murray

Abstract

The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

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Citations

Aug 5, 2017·Biomarkers in Medicine·Jinrong ZengQianjin Lu
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Herbert SchöchlChristoph J Schlimp
May 2, 2019·Genome Medicine·Henry Loeffler-WirthUNKNOWN German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma
Oct 22, 2020·PeerJ·Wanwan CaiWuzhou Yuan
Aug 11, 2021·Viruses·Yessica Sánchez-Ponce, Ezequiel M Fuentes-Pananá

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