PMID: 9170412Apr 15, 1997Paper

Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
Ramit Mehr, A S Perelson

Abstract

We present a model of the dynamics of CD4 and CD8 T-cell subsets in the thymus and peripheral blood and use it to study the blind homeostasis hypothesis, which states that the total T-cell population in the periphery is subject to regulation rather than regulation of the CD4 or CD8 subsets individually. Our model reconstructs experimental observations by Adleman and Wofsy on the effects of CD4+ T-cell depletion in mice. Our results point to the importance of the thymus in recovery from CD4+ T-cell depletion and particularly to the need to hypothesize an intrathymic feedback regulation of T-cell production exerted by CD4+ T cells. Our results support the blind homeostasis hypothesis for regulation of the peripheral blood levels of CD4+ and CD8- T cells.

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Citations

Jun 24, 2006·Bulletin of Mathematical Biology·Ramit Mehr
Apr 30, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Z GrossmanN Intrator
Jun 24, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·D E KirschnerA S Perelson
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Steven R DuncanArgyrios N Theofilopoulos
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·S J GangeJ B Margolick
Nov 10, 2015·Journal of Theoretical Biology·Hans H DiebnerIngo Roeder
Jan 15, 2005·AIDS Research and Human Retroviruses·Filippo CastiglioneMassimo Bernaschi
Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Seema H BajariaDenise Kirschner
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping Ye, Denise E Kirschner
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Véronique Thomas-VaslinDavid Klatzmann

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