Blind vaginal fetal fibronectin swab for prediction of preterm birth

The Journal of Obstetrics and Gynaecology Research
Amr H FaragHossameldin A Salama

Abstract

To assess the accuracy of blind vaginal swab in diagnosis of preterm labor (PTL) and prediction of subsequent occurrence of preterm birth (PTB). Eligible women who presented at 24-34 weeks of gestation with threatened PTL had their cervicovaginal secretions sequentially sampled for fetal fibronectin (fFN) using two types of swabbing techniques. The first swab was a blind vaginal swab collected without the aid of speculum, while the second one was a routine cervicovaginal swab. All participants were followed up until delivery. fFN in both swabs was significantly higher in women who delivered before term compared with women who delivered at term. On regression analysis, r(2) = 0.735 and 0.785 for blind vaginal and cervicovaginal swabs respectively, while on receiver operating characteristic analysis the area under curve was 0.965 and 0.977, respectively, without a statistically significant difference. Using an fFN cut-off of ≥0.05 μg/dL, the sensitivity, specificity, positive predictive value and negative predictive value of blind vaginal swab to predict PTB were 53.9%, 91.9%, 70.0% and 85.0%, respectively; while those for cervicovaginal swab were 58.3%, 94.7%, 77.8% and 87.8%, respectively. In women presenting at 24-34 weeks of ...Continue Reading

References

Sep 5, 1991·The New England Journal of Medicine·C J LockwoodT J Garite
Dec 17, 1998·American Journal of Obstetrics and Gynecology·M A ColemanM Mitchell
Feb 13, 2001·Obstetrics and Gynecology·G C LuW W Andrews
May 24, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Harald Leitich, Alexandra Kaider
Feb 3, 2005·Obstetrics and Gynecology·Ashley S RomanAndrei Rebarber
Jul 21, 2006·The Cochrane Database of Systematic Reviews·D Roberts, S Dalziel
Apr 25, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Valerie SmithShane Higgins
Mar 22, 2008·American Journal of Obstetrics and Gynecology·Irene P StaffordDaniel A Bloch
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Vincenzo BerghellaJason K Baxter
Jun 24, 2010·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amira El-Messidi, Alan Cameron
Mar 4, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gian Carlo Di RenzoYves Ville
May 15, 2012·Lancet·Li LiuUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
Sep 13, 2012·Archives of Gynecology and Obstetrics·Ibrahim A Abdelazim
Feb 12, 2013·Fertility and Sterility·Jamie A Bastek, Michal A Elovitz
May 31, 2013·The Journal of Obstetrics and Gynaecology Research·Moustafa I IbrahimEzz M Awad

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Citations

Jun 20, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gilles FaronLeonardo Gucciardo
Sep 15, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Khaled Abdel-MalekMazen Abdel-Rasheed

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