Blink rate in childhood-onset schizophrenia: comparison with normal and attention-deficit hyperactivity disorder controls

Biological Psychiatry
L K JacobsenJ L Rapoport

Abstract

Several lines of evidence have implicated central dopaminergic pathways in the modulation of blink rate. In the present study, blink rate during smooth pursuit was examined in 17 children with childhood-onset schizophrenia, on and off of clozapine, and compared to that of age-matched normal children and unmedicated children with attention-deficit hyperactivity disorder (ADHD). As has been observed in adolescent and adult schizophrenics, blink rate was significantly higher in schizophrenic children relative to normal and ADHD controls. Within the schizophrenic group, blink rate did not significantly change with the introduction of clozapine and was not related to clinical variables. Blink rate was positively correlated with deterioration in smooth pursuit in normal subjects.

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Citations

Jan 1, 1999·Electroencephalography and Clinical Neurophysiology·T MeierH Witte
Aug 24, 2002·Psychiatry and Clinical Neurosciences·Maki KojimaToshiyuki Someya
Aug 20, 2005·Journal of Intellectual Disability Research : JIDR·J E RobertsM L Boccia
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Mar 14, 2017·Infancy : the Official Journal of the International Society on Infant Studies·Leigh F BacherMartha Ann Bell

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