Block in nuclear localization of period protein by a second clock mutation, timeless

Science
L B VosshallM W Young

Abstract

In wild-type Drosophila, the period protein (PER) is found in nuclei of the eyes and brain, and PER immunoreactivity oscillates with a circadian rhythm. The studies described here indicate that the nuclear localization of PER is blocked by timeless (tim), a second chromosome mutation that, like per null mutations, abolishes circadian rhythms. PER fusion proteins without a conserved domain (PAS) and some flanking sequences are nuclear in tim mutants. This suggests that a segment of PER inhibits nuclear localization in tim mutants. The tim gene may have a role in establishing rhythms of PER abundance and nuclear localization in wild-type flies.

Citations

Jul 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J L Price
Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E RosatoC P Kyriacou
May 1, 1997·Bulletin of Mathematical Biology·R A BarrioP K Maini
Oct 23, 1998·Invertebrate Neuroscience : in·D S Saunders
Aug 30, 2008·Molecular Neurobiology·Raphaelle Dubruille, Patrick Emery
Oct 1, 1995·Neuroscience Research·N Ishida
Nov 1, 1995·Neuron·S M Reppert, I Sauman
Oct 1, 1995·Current Opinion in Genetics & Development·M Rosbash
Dec 1, 1995·Current Opinion in Neurobiology·A Sehgal
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Oct 24, 2000·Brain Research. Molecular Brain Research·M ZhuangJ C Besharse
May 25, 1999·Progress in Neurobiology·J Falcón
Mar 23, 2000·Progress in Neurobiology·J C HendricksA I Pack
Nov 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B Cymborowski, V King
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M E Hahn
Mar 26, 2002·The Pharmacogenomics Journal·J Hirsh
Jun 10, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T TakumiH Okamura
Feb 9, 2011·The Journal of Biological Chemistry·Joonseok ChaYi Liu
Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher J Reaume, Marla B Sokolowski
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·L SaezM W Young
May 1, 1995·Journal of Neuroendocrinology·M Hastings
Jun 10, 2000·Molecular and Cellular Biology·E VielhaberD M Virshup
Aug 25, 2000·Molecular and Cellular Biology·W V SoM Rosbash
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A Kaffman, E K O'Shea
Nov 1, 2001·Annual Review of Cell and Developmental Biology·S L HarmerS A Kay
Apr 13, 2000·Annual Review of Entomology·J M Giebultowicz
Jan 1, 1996·Annual Review of Genetics·J C Dunlap
Aug 25, 2001·Annual Review of Neuroscience·R AlladaM Rosbash
Feb 22, 2001·Annual Review of Physiology·J A Williams, A Sehgal
May 1, 2009·PLoS Biology·Johannes LandskronRalf Stanewsky

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