PMID: 7061984Jan 1, 1982

Block of inward rectification by intracellular H+ in immature oocytes of the starfish Mediaster aequalis

The Journal of General Physiology
W J Moody, S Hagiwara

Abstract

Intracellular pH was recorded in immature starfish oocytes using pH-sensitive microelectrodes, and inwardly rectifying potassium currents were measured under voltage clamp. When the intracellular pH was lowered using acetate-buffered artificial sea water from the normal value of 7.09 to 5.9, inward rectification was completely blocked. The relationship between inward rectification and internal pH between 7.09 and 5.9 could be fit by a titration curve for the binding of three H ions to a site with a pK of 6.26 to block the channel. The H+ block showed no voltage dependence, and the activation kinetics of the inwardly rectifying currents were not affected by the changes in internal pH.

References

Jan 1, 1976·The Journal of General Physiology·W F Boron, P De Weer
Nov 1, 1979·Nature·S S Shen, R A Steinhardt
May 1, 1975·The Journal of General Physiology·S HagiwaraO Sand
Dec 28, 1978·Pflügers Archiv : European journal of physiology·N B Standen, P R Stanfield
Oct 1, 1979·Pflügers Archiv : European journal of physiology·W Schwarz
Jan 1, 1978·Developmental Biology·L A Jaffe, K R Robinson
Oct 1, 1978·The Journal of General Physiology·B Hille, W Schwarz
Jun 1, 1973·The Journal of General Physiology·A M Woodhull
Jan 1, 1974·The Journal of Membrane Biology·S Hagiwara, K Takahashi
Jan 1, 1969·Progress in Biophysics and Molecular Biology·R H Adrian

Citations

Apr 1, 1990·Pflügers Archiv : European journal of physiology·T Ohno-ShosakuM Fujimoto
Dec 1, 1992·Pflügers Archiv : European journal of physiology·H ItoE Carmeliet
Jan 1, 1987·The Journal of Membrane Biology·D A KlaerkeP L Jørgensen
Feb 1, 1985·Developmental Biology·D J Webb, R Nuccitelli
Jan 1, 1996·Neuroscience Research·K I Takahashi, D R Copenhagen
Jan 1, 1992·Progress in Neurobiology·M Inoue, M Yoshii
Mar 15, 1996·Neuroscience Letters·C Eder, U Heinemann
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J Moody, J B Lansman
Aug 17, 2001·The Journal of Physiology·B BennettsG Y Rychkov
May 1, 1985·Pflügers Archiv : European journal of physiology·P P Van Bogaert
Mar 10, 1998·The Journal of Physiology·M TareT B Bolton
Sep 1, 1982·Pflügers Archiv : European journal of physiology·Y Kurachi
Aug 1, 1984·Pflügers Archiv : European journal of physiology·A L Blatz
Jul 19, 1996·The Journal of Biological Chemistry·T DoiJ P Ruppersberg
Mar 29, 2003·Physiological Reviews·Thomas E Decoursey
Apr 30, 1998·Physiological Reviews·K Takahashi, Y Okamura
Sep 8, 2001·American Journal of Physiology. Cell Physiology·A K StewartS L Alper

Related Concepts

Hydrogen-Ion Concentration
Resting Potentials
Oocytes
Ovum
Potassium
Seawater
Starfish

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