PMID: 7518058Feb 28, 1994Paper

Block of nicotinic acetylcholine-activated channels of cultured mouse myotubes by isoflurane

Neuroscience Letters
J BuflerC Franke

Abstract

It is well known that volatile anesthetics cause muscle relaxation. A block of nicotinic acetylcholine-activated receptors (nAChRs) in staedy state by isoflurane was recently reported. Pulses of acetylcholine (ACh) were applied to outside-out patches from mouse myotubes using a system for ultra-fast solution exchange allowing the study of the block of nAChRs by isoflurane under conditions similar to the situation during synaptic transmission. Isoflurane in concentrations used during general anesthesia blocked approximately 50% of the receptors within 0.5 ms after application. The block of nAChRs could be partially relieved by application of high concentrations of ACh. Therefore, muscle relaxation and the reduction of the amplitude of postsynaptic currents by isoflurane may be caused by the block of nAChRs reported here.

References

Apr 1, 1992·Pflügers Archiv : European journal of physiology·J P Dilger, Y Liu
Jun 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B W Urban, D A Haydon
Nov 28, 1989·European Journal of Pharmacology·M D SokollD Q Zwagerman
May 1, 1989·Biophysical Journal·H ParnasM E Spira
Mar 1, 1981·The Journal of General Physiology·B P BeanD A Goldstein
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J Lechleiter, R Gruener

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Citations

Apr 22, 2004·Neuromuscular Disorders : NMD·Friedrich SchlesingerJohannes Bufler
Feb 19, 2002·Brain Research Bulletin·Edömer TassonyiDaniel Bertrand
Feb 27, 1999·Toxicology Letters·B W Urban, P Friederich

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