Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yong Chul LeeUh-Hyun Kim

Abstract

Oxidative stress plays an important role in the pathogenesis of bronchial asthma. An excess production of reactive oxygen species (ROS) and defective endogenous antioxidant defense mechanisms may be present in asthma. Reduced glutathione (GSH) is one of the most important reducing agents against oxidant free radicals. A reducing agent, L-2-oxothiazolidine-4-carboxylic acid (OTC), a prodrug of cysteine, increases intracellular GSH. We have used a mouse model for asthma to determine effects of OTC on allergen-induced bronchial inflammation and airway hyper-responsiveness. The administration of OTC reduced bronchial inflammation and airway hyper-responsiveness. ROS generation in bronchoalveolar lavage fluids was increased by ovalbumin (OVA) inhalation, but this increase was diminished by administration of OTC. The increased IL-4, IL-5, IL-13, and eosinophil cationic protein levels in lungs after OVA inhalation were significantly reduced by the administration of OTC. In addition, the increased expression of ICAM-1, VCAM-1, RANTES, and eotaxin in lungs after OVA inhalation was significantly reduced by the administration of OTC. We also showed that the increased NF-kappaB levels in nuclear protein extracts of lung tissues at 72 h aft...Continue Reading

References

Aug 22, 1991·The New England Journal of Medicine·S OwenA Woodcock
May 1, 1986·Toxicology and Applied Pharmacology·G A HazeltonC D Klaassen
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J M Williamson, A Meister
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M WilliamsonA Meister
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SchenkK Schulze-Osthoff
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·A R HulsmannJ C de Jongste
Jun 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C AstiC Omini
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·I RahmanW MacNee
Jan 1, 1996·Free Radical Biology & Medicine·I Rahman, W MacNee
Feb 1, 1997·Trends in Pharmacological Sciences·P J Barnes, I M Adcock
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Sep 1, 1999·Free Radical Biology & Medicine·J CortijoE J Morcillo
Sep 3, 1999·The Journal of Biological Chemistry·L AdamT L Jones
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Sep 19, 2000·Thorax·R Dworski
Nov 8, 2001·European Journal of Pharmacology·W MacNee
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S BlesaE J Morcillo
Feb 28, 2002·Free Radical Biology & Medicine·Minjie ZhangKiyohisa Sekizawa
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong C LeeChang H Song
Aug 16, 2002·Free Radical Research·Shozo NishidaKiyohiro Irimajiri
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·William R HendersonMichael Kahn
Apr 3, 2003·The Journal of Clinical Investigation·Yong-Geun KwakYong C Lee

❮ Previous
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Citations

Feb 7, 2012·Antioxidants & Redox Signaling·Anne M FitzpatrickLou Ann S Brown
Jan 16, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hee Sun ParkYong Chul Lee
Apr 24, 2010·American Journal of Respiratory and Critical Care Medicine·So Ri KimYong Chul Lee
Apr 1, 2006·American Journal of Respiratory Cell and Molecular Biology·Kyung Sun LeeYong Chul Lee
May 19, 2009·American Journal of Respiratory Cell and Molecular Biology·Kyung-Jin ChoJae-Hong Kim
Jul 3, 2010·American Journal of Respiratory Cell and Molecular Biology·Sandra HodgePaul N Reynolds
Jun 17, 2006·Journal of Inflammation·Ronald D Mathison, Joseph S Davison
Mar 16, 2011·International Journal of General Medicine·Pietro Ghezzi
May 22, 2013·Mediators of Inflammation·I-Ta Lee, Chuen-Mao Yang
Mar 20, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiwon ChoiSeon-Il Jang
May 17, 2012·Biochemical Pharmacology·I-Ta Lee, Chuen-Mao Yang
Feb 2, 2011·Biochimica Et Biophysica Acta·Niki L Reynaert
Sep 11, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Meshal Al MoutaeryMohammad Tariq
Jul 8, 2008·International Immunopharmacology·Wei JiYuhua Qiu
May 22, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sang-Joon ParkEun-Joo Kim
Aug 7, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M S S OliveiraP M R e Silva
Nov 26, 2010·Phytotherapy Research : PTR·Mee-Young LeeHyeun-Kyoo Shin
Sep 13, 2015·International Immunopharmacology·Manar A Nader
May 7, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·José Hidelbland Cavalcante de FariasFlávia Raquel Fernandes do Nascimento
Oct 7, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hee Sun ParkYong Chul Lee
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Martinez-LosaE J Morcillo
Dec 14, 2007·Immunopharmacology and Immunotoxicology·Ken-Ichiro InoueToshikazu Yoshikawa
Jun 11, 2019·Journal of Cellular Physiology·Josiane Silva SilveiraAline Andrea da Cunha
Jul 11, 2006·Molecular Pharmacology·Kyung Sun LeeYong Chul Lee
Jan 9, 2008·International Journal of Immunopathology and Pharmacology·K InoueT Yoshikawa
May 8, 2020·Molecular Biology Reports·Xiaomei LiuBaochun Zhao
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niki L ReynaertYvonne M W Janssen-Heininger
Jan 12, 2008·Current Opinion in Allergy and Clinical Immunology·Nilesh DharajiyaSanjiv Sur
May 18, 2020·International Archives of Allergy and Immunology·Jing ZhouYunhai Feng

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