PMID: 15240731Jul 9, 2004Paper

Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody

The Journal of Immunology : Official Journal of the American Association of Immunologists
Suresh RadhakrishnanLarry R Pease

Abstract

We present a novel immunotherapeutic strategy using a human B7-DC cross-linking Ab that prevents lung inflammation, airway obstruction, and hyperreactivity to allergen in a mouse model of allergic inflammatory airway disease. Dendritic cells (DC) have the ability to skew the immune response toward a Th1 or Th2 polarity. The sHIgM12 Ab functions in vitro by cross-linking the costimulatory family molecule B7-DC (PD-L2) on DC up-regulating IL-12 production, homing to lymph nodes, and T cell-activating potential of these APCs. Using chicken OVA as a model Ag, the administration of sHIgM12 Ab to BALB/c mice blocked lung inflammation, airway pathology, and responsiveness to methacholine, even after animals were presensitized and a Th2-polarized immune response was established. This therapeutic strategy was ineffective in STAT4-deficient animals, indicating that IL-12 production is critical in this system. Moreover, the polarity of the immune response upon in vitro restimulation with Ag is changed in wild-type mice, with a resulting decrease in Th2 cytokines IL-4 and IL-5 and an increase in the immunoregulatory cytokine IL-10. These studies demonstrate that the immune response of hypersensitized responders can be modulated using B7-DC...Continue Reading

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Citations

Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·Omid Akbari, Dale T Umetsu
Jun 11, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Elena V Dmitrieva-ZdorovaOlga E Voronko
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suresh RadhakrishnanLarry R Pease
Jul 1, 2005·Expert Review of Clinical Immunology·Jagadeesh BayrySrini V Kaveri
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Jan 22, 2005·Current Allergy and Asthma Reports·Omid Akbari, Dale T Umetsu
Jan 4, 2007·The Journal of Experimental Medicine·Tomoki ItoMichel Gilliet
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroichi NagaiTeruo Tuchiya
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun-Sang J SungSteven R Beaty
Jun 3, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Larry R Pease
Sep 27, 2008·European Journal of Immunology·Karin L HeckmanLarry R Pease
Jun 6, 2007·European Journal of Immunology·Karin L HeckmanLarry R Pease
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suresh RadhakrishnanLarry R Pease
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jagadeesh BayrySrini V Kaveri
Jan 18, 2006·Clinical and Experimental Immunology·V P Van KeulenL R Pease
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Suresh RadhakrishnanLarry R Pease
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suresh RadhakrishnanLarry R Pease

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