Blockade of CD40-CD154 at the time of donor-specific blood transfusion does not lead to prolonged kidney allograft survival in nonhuman primates

Transplantation
Jan RingersMargreet Jonker

Abstract

In rodents it has been demonstrated that blockade of the CD40-CD154 (CD40L) pathway at the time of donor-specific blood transfusion (DST) can result in indefinite graft survival. Because it has been reported in the past that DST in monkeys can have a favorable effect on graft outcome and that blockade of the CD40-CD154 pathway can lead to prolonged kidney graft survival in monkeys, we have combined anti-CD154 treatment with DST in a monkey kidney graft model. The aim of this study was to investigate the immunosuppressive potential of blocking the CD40-CD154 interaction at the time of a DST in rhesus monkeys. One donor-derived blood transfusion was given on day -15 after the first anti-CD154 injection. The anti-CD154 antibody was given on days -15, -13, -11, -9, and -7. The kidney was transplanted on day 0. Cyclosporine was given after kidney trans-plantation. No major difference in graft survival was observed between the groups. The animals died due to grade II acute rejection. At the time of transplantation, no antibody response could be detected directed against donor antigens. After transplantation, all animals surviving for more than 3 weeks had antidonor antibodies. There were no differences in the intragraft events analyz...Continue Reading

References

Dec 1, 1992·European Journal of Immunology·D GrafR A Kroczek
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Jun 19, 1998·The New England Journal of Medicine·M H Sayegh, L A Turka
Dec 3, 1998·The Journal of Clinical Investigation·R JosienM C Cuturi
Feb 2, 2000·Nature Medicine·V R DharnidharkaS Skoda-Smith
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C P YangE B Bell
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G G DoxiadisR E Bontrop

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Citations

Dec 21, 2002·Transplantation Proceedings·M GambararaF D'Orio
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Douglas A HaleAllan D Kirk
Jun 5, 2007·Heart Failure Clinics·Richard N Pierson
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Edwin H PrestonAllan D Kirk
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K K DhanireddyA D Kirk
Jul 10, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H G KangX X Zheng
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K G HaanstraM Jonker
Sep 24, 2004·Transplant Immunology·Thomas Fehr, Megan Sykes

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