PMID: 6105337Jul 26, 1980Paper

Blockade of chlorpropamide-alcohol flushing by indomethacin suggests an association between prostaglandins and diabetic vascular complications

Lancet
A H BarnettD A Pyke

Abstract

Chlorpropamide/alcohol flushing (CPAF), found in many patients with non-insulin-dependent diabetes (NIDD), can be blocked by indomethacin in most patients who are free of vascular complications but not in those with such complications. Since indomethacin is a prostaglandin inhibitor this finding suggests that prostaglandins may be involved in the aetiology of vascular diseases in NIDD. All 6 pairs of identical twins with CPAF, of whom 2 pairs were disocrdant for diabetes, were concordant for indomethacin blocking, which suggests that the block has a genetic basis. The difference in the response of CPAF to indomethacin in diabetic patients with and without vascular complications is probably the first indication of a metabolic difference between these two types of patient.

References

Feb 10, 1979·Lancet·M JohnsonJ B Elder
May 12, 1979·Lancet·R D LeslieD A Pyke
Oct 13, 1979·Lancet·T M DavisR C Turner
Dec 22, 1979·Lancet·C T DolleryJ Webster
Feb 15, 1979·The New England Journal of Medicine·M SchydlowerP H Patterson
Dec 2, 1978·British Medical Journal·R D Leslie, D A Pyke
Feb 23, 1980·Lancet·C R StrakoschH Keen
Jul 4, 1964·Lancet·E D POWELL, R A FIELD

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Citations

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·W B PickworthJ E Henningfield
Mar 1, 1990·Alcohol·D P MikhailidisJ Y Jeremy
Mar 21, 1981·Lancet
Apr 4, 1981·Lancet·W S Phillips, S L Lightman
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C J Eriksson
Oct 10, 1981·British Medical Journal·S MedbakL H Rees
Mar 25, 1989·BMJ : British Medical Journal·J L Burton
Apr 1, 1983·Journal of Clinical Pathology·V Marks
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·S B HoJ I Allen
Jun 1, 1983·Drug and Alcohol Dependence·J Parantainen
Nov 1, 1984·Clinical Endocrinology·C JohnstonL H Rees
Jan 1, 1983·Acta Medica Scandinavica·L E Böttiger
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R W Stout

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