Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis

The Journal of Pharmacology and Experimental Therapeutics
Sakae MikamiTsutomu Chiba

Abstract

Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several inflammatory conditions. However, it is unclear whether this interaction has a role in the pathophysiology of inflammatory bowel disease (IBD). We investigated the significance of this interaction in patients with IBD and in mice with dextran sulfate sodium (DSS)-induced colitis and the effect of a CXCR4 antagonist on experimental colitis. First, we measured CXCR4 expression on peripheral T cells in patients with IBD. Furthermore, we investigated CXCR4 expression on leukocytes and CXCL12 expression in the colonic tissue of mice with DSS-induced colitis, and we evaluated the effects of a CXCR4 antagonist on DSS-induced colitis and colonic inflammation of interleukin (IL)-10 knockout (KO) mice. Colonic inflammation was assessed both clinically and histologically. Cytokine production from mesenteric lymph node cells was also examined. CXCR4 expression on peripheral T cells was significantly higher in patients with active ulcerative colitis (UC) compared with normal controls, and CXCR4 expression levels of UC patients correlated with disease activity. Both CXCR4 expression on leukocytes and CXCL12 expression in colonic tissue were significantly increas...Continue Reading

References

Jul 3, 1998·Gastroenterology·C Fiocchi
May 20, 1999·Journal of Leukocyte Biology·F AnnunziatoE Maggi
Jan 13, 2000·Current Opinion in Immunology·R S BlumbergW Strober
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NankiP E Lipsky
Dec 6, 2000·The Journal of Clinical Investigation·T PonomaryovT Lapidot
Feb 1, 2002·Nature Medicine·Bernhard HomeyAlbert Zlotnik
May 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ryo TeradaYasushi Shiratori
Dec 3, 2003·Organic & Biomolecular Chemistry·Hirokazu TamamuraNobutaka Fujii
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·S John CurnowMike Salmon
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiroyuki OgawaMartin F Kagnoff
Sep 1, 2004·European Journal of Pharmacology·Maureen N AjueborCory M Hogaboam
Dec 2, 2005·Arthritis and Rheumatism·Christian S HaasAlisa E Koch
Feb 4, 2006·Current Drug Targets·K GijsbersJ Van Damme

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Citations

Sep 24, 2009·Inflammatory Bowel Diseases·Iris DotanHanan Guzner-Gur
Mar 7, 2012·Immunologic Research·Miljana MomcilovićDjordje Miljković
Dec 10, 2008·The Journal of Biological Chemistry·Zinaida DubeykovskayaTimothy C Wang
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Lauren ArmsMargaret A Vizzard
Jun 27, 2009·BMC Medical Genomics·John W GowAbhijit Chaudhuri
Apr 10, 2012·PloS One·Zhongxing LiangHyunsuk Shim
Apr 4, 2014·PloS One·Silvana ZgraggenMichael Detmar
Jun 18, 2010·World Journal of Gastroenterology : WJG·Xian-Ming XiaYun-Zhu Shen
Apr 17, 2014·BioMed Research International·Eric J GonzalezMargaret A Vizzard
Mar 10, 2010·Cellular and Molecular Life Sciences : CMLS·Hans-Dieter Flad, Ernst Brandt
Aug 16, 2011·Pharmacology & Therapeutics·Pim J KoelinkAletta D Kraneveld
Sep 6, 2012·Journal of Internal Medicine·J Marsal, W W Agace
Mar 17, 2009·Cell Adhesion & Migration·Miroslaw Janowski
Oct 22, 2013·Gut·Ishan RoyMichael B Dwinell
Mar 29, 2011·Analytical Biochemistry·Etienne MalvoisinNadine Vincent
Aug 11, 2016·Inflammatory Bowel Diseases·Dylan K McDanielIrving C Allen
May 4, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Noah P ZimmermanMichael B Dwinell
Nov 28, 2013·Current Opinion in Hematology·Stephanie HummelAlexander Zarbock
Feb 20, 2020·Inflammatory Bowel Diseases·Daisuke OkamotoAtsushi Masamune
Aug 3, 2017·Medicinal Research Reviews·Lun Kelvin TsouKak-Shan Shia
Apr 2, 2014·Molecular Biology Reports·Jerzy MrowickiIreneusz Majsterek
Sep 12, 2019·Frontiers in Endocrinology·Eva M García-CuestaMario Mellado
Aug 19, 2018·European Journal of Nutrition·Yueting GeTongcheng Xu
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofie StruyfPaul Proost
Jun 27, 2019·Scientific Reports·Tania SinghIsabella Artner
Dec 25, 2019·Seminars in Cancer Biology·Sara K DanielVenu G Pillarisetty

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