Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system.

Neuroscience
G A MarksC G Birabil

Abstract

The brainstem reticular formation is an area important to the control of rapid eye movement (REM) sleep. The antagonist of GABA-type A (GABA(A)) receptors, bicuculline methiodide (BMI), injected into the rat nucleus pontis oralis (PnO) of the reticular formation resulted in a long-lasting increase in REM sleep. Thus, one factor controlling REM sleep appears to be the number of functional GABA(A) receptors in the PnO. The long-lasting effect produced by BMI may result from secondary influences on other neurotransmitter systems known to have long-lasting effects. To study this question, rats were surgically prepared for chronic sleep recording and additionally implanted with guide cannulas aimed at sites in the PnO. Multiple, 60 nl, unilateral injections were made either singly or in combination. GABA(A) receptor antagonists, BMI and gabazine (GBZ), produced dose-dependent increases in REM sleep with GBZ being approximately 35 times more potent than BMI. GBZ and the cholinergic agonist, carbachol, produced very similar results, both increasing REM sleep for about 8 h, mainly through increased period frequency, with little reduction in REM latency. Pre-injection of the muscarinic antagonist, atropine, completely blocked the REM sl...Continue Reading

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Feb 24, 2007·Brain Research·Gerald A Marks, Christian G Birabil

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Citations

Jul 10, 2013·Brain Research·Tin Quang NguyenGerald A Marks
Sep 29, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vineet C ChitravanshiHreday N Sapru
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·RaShonda R FlintHelen A Baghdoyan
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giancarlo VaniniHelen A Baghdoyan
Feb 26, 2016·Brain : a Journal of Neurology·Evangelia EmmanouilidouKostas Vekrellis
Nov 20, 2012·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Feb 1, 2011·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Aug 22, 2009·Brain Research Reviews·Alan M Rosenwasser
Jun 18, 2011·Journal of Neurochemistry·Christopher J WatsonHelen A Baghdoyan
Jun 9, 2016·PloS One·Panayotis K ThanosNora D Volkow
Jul 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Pierre Changeux, Hans C Lou
Feb 27, 2013·Current Anesthesiology Reports·Matthew T Scharf, Max B Kelz
Oct 17, 2014·Expert Review of Clinical Pharmacology·Dan M McEntireCharles F Youngblood

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