Blockade of hedgehog pathway is required for the protective effects of magnesium isoglycyrrhizinate against ethanol-induced hepatocyte steatosis and apoptosis

IUBMB Life
Chunfeng LuShi-Zhong Zheng

Abstract

Alcoholic liver disease (ALD), characterized by excessive deposition of lipids in hepatocytes, causes heavy health burden personally and socially. Mechanistically, hedgehog signaling was activated during the development of ALD, and exerted compelling role in regulating lipometabolism. The current promising intervention strategy is inhibition of lipid accumulation and apoptosis in hepatocytes. Magnesium isoglycyrrhizinate (MgIG) has been widely used in various liver diseases for its good hepatoprotective activities. However, the role of MgIG in ALD has not been elucidated. Therefore, this study was aimed to explore the role of MgIG and further identify the potential mechanisms. We found for the first time that MgIG reduced lipid accumulation, including triglyceride, and total cholesterol, probably via inducing peroxisome proliferator-activated receptor-alpha and inhibiting sterol regulatory element-binding protein-1c. Further, MgIG alleviated ethanol-induced oxidative stress, evidenced by reduced abundance of reactive oxygen species and increased levels of glutathione, superoxide dismutase, and mitochondrial transmembrane potential. Besides, MgIG protected hepatocytes from ethanol-induced apoptosis. In addition, MgIG dose-depend...Continue Reading

References

Dec 17, 2003·Journal of Gastroenterology and Hepatology·Paul S HaberGeoffrey W McCaughan
Dec 16, 2006·Current Drug Metabolism·Ian A Blair
Dec 17, 2008·Developmental Cell·Jin Jiang, Chi-Chung Hui
Dec 9, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Bin ChengChunyan Liu
Apr 7, 2010·Clinical Lipidology·Sophie C Cazanave, Gregory J Gores
Jul 10, 2010·International Journal of Environmental Research and Public Health·Rui Guo, Jun Ren
Nov 9, 2010·The International Journal of Biochemistry & Cell Biology·Steve S ChoiAnna Mae Diehl
May 4, 2011·Seminars in Liver Disease·Quentin M AnsteeChristopher P Day
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Dec 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tao ZengKe-Qin Xie
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cynthia D GuyUNKNOWN NASH CRN
Dec 18, 2013·Antimicrobial Agents and Chemotherapy·Vandana SinghBhupendra N Singh
Apr 7, 2015·Free Radical Biology & Medicine·M Pilar ValdecantosÁngela M Valverde
Oct 16, 2015·International Immunopharmacology·Chunfeng LuShizhong Zheng
Oct 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyunjoo KwonTong Wu
May 8, 2016·Journal of Hepatology·Giovanni AddoloratoAntoni Gual
Oct 21, 2016·British Journal of Pharmacology·Nermeen N El-AgroudyEbtehal El-Demerdash

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Citations

Jun 5, 2019·International Journal of Molecular Sciences·Ling-Zu KongTaeho Kwon
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miao SuiYan Zhu
Jul 1, 2021·Toxicology Letters·Ruoman WuChunfeng Lu

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis