Abstract
Alcoholic liver disease (ALD), characterized by excessive deposition of lipids in hepatocytes, causes heavy health burden personally and socially. Mechanistically, hedgehog signaling was activated during the development of ALD, and exerted compelling role in regulating lipometabolism. The current promising intervention strategy is inhibition of lipid accumulation and apoptosis in hepatocytes. Magnesium isoglycyrrhizinate (MgIG) has been widely used in various liver diseases for its good hepatoprotective activities. However, the role of MgIG in ALD has not been elucidated. Therefore, this study was aimed to explore the role of MgIG and further identify the potential mechanisms. We found for the first time that MgIG reduced lipid accumulation, including triglyceride, and total cholesterol, probably via inducing peroxisome proliferator-activated receptor-alpha and inhibiting sterol regulatory element-binding protein-1c. Further, MgIG alleviated ethanol-induced oxidative stress, evidenced by reduced abundance of reactive oxygen species and increased levels of glutathione, superoxide dismutase, and mitochondrial transmembrane potential. Besides, MgIG protected hepatocytes from ethanol-induced apoptosis. In addition, MgIG dose-depend...Continue Reading
References
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Paul S HaberGeoffrey W McCaughan
Jan 27, 2005·Alcohol·David W CrabbMin You
Aug 2, 2006·Journal of Hepatology·Cheng JiNeil Kaplowitz
Dec 16, 2006·Current Drug Metabolism·Ian A Blair
Apr 6, 2007·Journal of Clinical Pharmacology·Li SunMinde Zeng
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Ting-Kai Li
May 13, 2008·Gastroenterology·Youngmi JungAnna Mae Diehl
Dec 17, 2008·Developmental Cell·Jin Jiang, Chi-Chung Hui
Jun 11, 2009·International Journal of Oncology·Yuriko Katoh, Masaru Katoh
Sep 16, 2009·Pharmacology·Yuan ChengLuyong Zhang
Dec 9, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Bin ChengChunyan Liu
Apr 7, 2010·Clinical Lipidology·Sophie C Cazanave, Gregory J Gores
Jul 10, 2010·International Journal of Environmental Research and Public Health·Rui Guo, Jun Ren
Aug 19, 2010·Journal of Cellular Biochemistry·Woo-Kyun KimFarhad Parhami
Nov 9, 2010·The International Journal of Biochemistry & Cell Biology·Steve S ChoiAnna Mae Diehl
May 4, 2011·Seminars in Liver Disease·Quentin M AnsteeChristopher P Day
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Dec 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tao ZengKe-Qin Xie
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cynthia D GuyUNKNOWN NASH CRN
Sep 3, 2013·Chemico-biological Interactions·Li ChenShizhong Zheng
Oct 30, 2013·Alcoholism, Clinical and Experimental Research·Isaac S ChanAnna Mae Diehl
Dec 18, 2013·Antimicrobial Agents and Chemotherapy·Vandana SinghBhupendra N Singh
May 9, 2014·Transplantation·René FahrnerGuido Beldi
Apr 7, 2015·Free Radical Biology & Medicine·M Pilar ValdecantosÁngela M Valverde
Aug 26, 2015·IUBMB Life·Chunfeng LuShizhong Zheng
Sep 6, 2015·Life Sciences·Chunfeng LuShizhong Zheng
Oct 16, 2015·International Immunopharmacology·Chunfeng LuShizhong Zheng
Oct 17, 2015·Journal of Hepatology·Sook In ChungSimon Weonsang Ro
Oct 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyunjoo KwonTong Wu
Jan 27, 2016·Journal of Hepatology·Laurent Dubuquoy
Mar 31, 2016·IUBMB Life·Wenxuan XuShizhong Zheng
May 8, 2016·Journal of Hepatology·Giovanni AddoloratoAntoni Gual
Oct 21, 2016·British Journal of Pharmacology·Nermeen N El-AgroudyEbtehal El-Demerdash
Nov 1, 2016·Molecular Pharmaceutics·Chunfeng LuShizhong Zheng
Citations
Sep 9, 2017·Transplantation·Weichen ZhangShusen Zheng
Jun 5, 2019·International Journal of Molecular Sciences·Ling-Zu KongTaeho Kwon
Oct 16, 2018·Frontiers in Pharmacology·Jie Kai TeeHan Kiat Ho
Jul 3, 2019·IUBMB Life·Xingran ChenShizhong Zheng
Oct 20, 2017·BioFactors·Mianli BianShizhong Zheng
Apr 12, 2019·Frontiers in Pharmacology·Yuzhu CaoYin Lu
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miao SuiYan Zhu
Mar 16, 2021·Frontiers in Pharmacology·Yuqi LaiZhiping Lv
Jul 1, 2021·Toxicology Letters·Ruoman WuChunfeng Lu
Sep 2, 2021·The Journal of Pharmacy and Pharmacology·Xiaoling ChenChong Xu
Sep 3, 2021·Toxicology·Yunyun ShaoChunfeng Lu
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li LiHua Bian