PMID: 15240736Jul 9, 2004Paper

Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yali ChenKevan C Herold

Abstract

Ligation of the receptor for advanced glycation end products (RAGE) occurs during inflammation. Engagement of RAGE results in enhanced expression of addressins and it is therefore, not surprising that previous studies have shown a role of RAGE/ligand interactions in immune responses including cell/cell contact but the role of RAGE in spontaneous autoimmunity has not been clearly defined. To study the role of RAGE/ligand interactions in autoimmune diabetes, we tested the ability of soluble RAGE, a scavenger of RAGE ligands, in late stages of diabetes development in the NOD mouse-disease transferred with diabetogenic T cells and recurrent disease in NOD/scid recipients of syngeneic islet transplants. RAGE expression was detected on CD4(+), CD8(+), and B cells from diabetic mice and transferred to NOD/scid recipients. RAGE and its ligand, S100B, were found in the islets of NOD/scid mice that developed diabetes. Treatment of recipient NOD/scid mice with soluble RAGE prevented transfer of diabetes and delayed recurrent disease in syngeneic islet transplants. RAGE blockade was associated with increased expression of IL-10 and TGF-beta in the islets from protected mice. RAGE blockade reduced the transfer of disease with enriched T cel...Continue Reading

References

Oct 1, 1992·The Journal of Experimental Medicine·K C HeroldF Buckingham
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KitaniW Strober
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·A M Schmidt, D M Stern
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Nov 28, 2001·Immunological Reviews·M G RoncaroloM K Levings
Jan 12, 2002·Kidney International·Eric BoulangerPhilippe Dequiedt
Sep 25, 2003·Annals of Clinical Biochemistry·Z TurkA Stavljenić-Rukavina
Oct 22, 2003·Archives of Biochemistry and Biophysics·George JerumsMark Cooper
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shan ZengJean C Emond

❮ Previous
Next ❯

Citations

May 3, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Barry I HudsonAnn Marie Schmidt
Sep 1, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angelika BierhausPeter P Nawroth
Nov 25, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Clair M SullivanPeter J Grant
Apr 28, 2006·Current Atherosclerosis Reports·Shi Fang YanAnn Marie Schmidt
Dec 15, 2007·The Journal of Clinical Investigation·Evis HarjaAnn Marie Schmidt
Mar 12, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Shi Fang YanAnn Marie Schmidt
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernhard MoserRaphael Clynes
May 30, 2009·Journal of Leukocyte Biology·Ravichandran RamasamyAnn Marie Schmidt
Jan 4, 2012·Annals of the New York Academy of Sciences·Ravichandran RamasamyAnn Marie Schmidt
Jan 11, 2013·Physiological Reviews·Josephine M Forbes, Mark E Cooper
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Dong XuYong-Qing Yang
Sep 20, 2015·International Journal of Immunogenetics·X WuY Li
Mar 12, 2009·Clinical Science·Anastasia Z KaleaBarry I Hudson
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yali ChenKevan C Herold
Apr 2, 2013·Journal of Leukocyte Biology·Katrin Kierdorf, Günter Fritz
Jun 1, 2016·Frontiers in Cellular Neuroscience·Judyta K JuranekAnn Marie Schmidt
Mar 8, 2005·Current Hypertension Reports·Georgia SoldatosKarin A M Jandeleit-Dahm
Jan 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B MoserA M Schmidt
Feb 9, 2005·The Journal of Experimental Medicine·Guellue CataldegirmenJean C Emond
Jan 9, 2013·Nature Reviews. Endocrinology·Brooke E HarcourtJosephine M Forbes
Sep 14, 2011·Diabetes·Melinda T CoughlanJosephine M Forbes
Sep 23, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sean P DurningUNKNOWN Type 1 Diabetes TrialNet Study Group
Mar 1, 2020·Medicinal Research Reviews·Selena Le BaggeJosephine M Forbes
Oct 13, 2007·Molecular Medicine·Hidenori KoyamaYoshiki Nishizawa
Jul 23, 2005·Annals of the New York Academy of Sciences·William KimAnn Marie Schmidt
Oct 15, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Hidenori KoyamaYoshiki Nishizawa
Feb 4, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shi Fang YanAnn Marie Schmidt
Dec 5, 2012·The Journal of Experimental Medicine·Vivek RaiAnn Marie Schmidt
Apr 28, 2010·Nature Reviews. Nephrology·Vivette D'Agati, Ann Marie Schmidt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.