PMID: 8938824Oct 1, 1996Paper

Blockade of metabotropic glutamate receptors protects hippocampal neurons from hypoxia-induced cell death in rat in vivo

Progress in Neuro-psychopharmacology & Biological Psychiatry
G RiedelK G Reymann

Abstract

1. In this pilot study the authors examined the role of hippocampal metabotropic glutamate receptors (mGluRs) in hypoxia in vivo by determining frank neuronal cell death histologically 4 days after the first of three daily insults. 2. Adult male, Wistar rats, chronically prepared with cannulae, were intraventricularly injected with either saline or the metabotropic receptor antagonists L-AP3 (0.102 mg) or MCPG (0.208 mg) 30 min prior to hypoxic insult. 3. Histological analysis of hippocampal regions revealed attenuated neuronal cell loss in CA1 and CA3 in both L-AP3 and MCPG-treated animals. 4. These data suggest a participation of mGluRs in hypoxia-induced neuronal cell death.

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Citations

Feb 13, 1999·European Journal of Pharmacology·P Henrich-Noack, K G Reymann
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sunny E OhiaNajam A Sharif
Feb 11, 2000·Annals of the New York Academy of Sciences·A E KingstonD D Schoepp
Jun 18, 2005·Brain Research. Brain Research Reviews·Zhao Zhong ChongKenneth Maiese
Dec 22, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Catherine A OpereNajam A Sharif
Nov 19, 2004·Journal of Neurophysiology·Kenira J ThompsonJoe L Martinez

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