Blockade of methamphetamine-induced depression of tyrosine hydroxylase by GABA transaminase inhibitors

European Journal of Pharmacology
A Hotchkiss, J W Gibb

Abstract

Tyrosine hydroxylase (TH) levels in the rat neostriatum are decreased by chronic treatment with methamphetamine. GABAergic neurons could potentially interact with the nigrostriatal dopaminergic neurons in either the neostriatum or the substantia nigra; therefore, the GABA transaminase inhibitors, amino-oxyacetic acid, gamma-acetylenic GABA and ethanolamine-O-sulfate, were evaluated for possible influences on the methamphetamine-induced decrease in TH. TH was measured by the procedure of Nagatsu et al. (1964). Methamphetamine (10 mg/kg, s.c.) was given every 6 h for 24 h. Thirty-six h after initiation of the methamphetamine treatment, neostriatal TH activity was approximately 70% of control. Concurrent administration of amino-oxyacetic acid (20 mg/kg, i.p.) or gamma-acetylenic GABA (15 mg/kg, i.p.) with methamphetamine completely blocked the TH depression. Dose-response curves were constructed for amino-oxyacetic acid and gamma-acetylenic GABA. A single intraventricular injection of ethanolamine-O-sulfate (400 micrograms/rat), 2-6 h before initiating the methamphetamine regimen, also completely blocked the TH depression. These data suggest that the striatonigral or other GABAergic systems are involved in the regulation of the fu...Continue Reading

References

May 27, 1977·Brain Research·R Schwarcz, J T Coyle
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·J W Gibb, F J Kogan
Jul 15, 1975·Life Sciences·E CostaA Suria
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Apr 1, 1974·European Journal of Pharmacology·M K Buening, J W Gibb
Sep 1, 1964·Analytical Biochemistry·T NAGATSUS UDENFRIEND

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Citations

Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather A BogerJacqueline F McGinty
Nov 16, 2006·Annals of the New York Academy of Sciences·Ning Sheng CaiJean Lud Cadet
Nov 11, 2008·Annals of the New York Academy of Sciences·Michela FerrucciFrancesco Fornai
Oct 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean Lud CadetXiaolin Deng
Oct 21, 2009·Current Eye Research·Hong LaiShenghan Lai

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