PMID: 9533407Apr 9, 1998Paper

Blockade of morphine- and amphetamine-induced conditioned place preference in the rat by riluzole

Neuroscience Letters
T M Tzschentke, W J Schmidt

Abstract

Previous studies have shown that antagonists at glutamatergic N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) receptors can disrupt the development or expression, respectively, of conditioned place preference (CPP) induced by drugs of abuse. The present study examined the effects of inhibition of presynaptic glutamate release by riluzole on the development of morphine- and amphetamine-induced CPP. Morphine (10 mg/kg), D,L-amphetamine (4 mg/kg) and riluzole (4 mg/kg) itself each produced a significant CPP; however, when riluzole was co-administered with morphine or amphetamine during the conditioning sessions, no CPP developed. It is concluded that non-specific disruption of glutamatergic neurotransmission prevents the development of morphine- and amphetamine-induced CPP.

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Citations

Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Hedayat SahraeiMohammad Reza Zarrindast
Aug 19, 2003·European Journal of Pharmacology·Jolanta KotlinskaJerzy Silberring
Sep 28, 1999·European Journal of Pharmacology·J SepúlvedaE Contreras
Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Zargham SepehrizadehMousa Sahebgharani
Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·S Pournaghash TehraniH Sahraei
Nov 18, 2009·Pharmacology & Therapeutics·Bianca Jupp, Andrew J Lawrence
Aug 24, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mehmet SofuogluThomas Kosten
May 19, 2007·European Journal of Pharmacology·Mohammad-Reza ZarrindastFarzaneh Nazari-Serenjeh
May 12, 2009·Alcoholism, Clinical and Experimental Research·Joyce BesheerClyde W Hodge
Sep 24, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bruno Ribeiro Do CoutoJose Miñarro
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Dec 22, 2010·European Journal of Pharmacology·Carmen ManzanedoMarta Rodríguez-Arias
Oct 6, 2016·Journal of Psychopharmacology·Małgorzata H LehnerAdam Płaźnik
Dec 12, 2018·Journal of Psychopharmacology·Mohammad-Hadi FarahzadiShahin Akhondzadeh
Aug 9, 2007·Molecular Psychiatry·T L Lauriat, L A McInnes
Jun 13, 2017·The International Journal of Neuropsychopharmacology·Sade Spencer, Peter W Kalivas
Nov 8, 2020·Neurochemistry International·Kathryn D FischerPaul A Rosenberg
Apr 29, 2020·Cold Spring Harbor Perspectives in Medicine·Jasper A HeinsbroekJamie Peters

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