PMID: 9447870Feb 3, 1998Paper

Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cord

Anesthesiology
A OlschewskiB V Safronov

Abstract

The dorsal horn of the spinal cord is a pivotal point for transmission of neuronal pain. During spinal and epidural anesthesia, the neurons of the dorsal horn are exposed to local anesthetics. Unfortunately, little is known about the action of local anesthetics on the major ionic conductances in dorsal horn neurons. In this article, the authors describe the effects of bupivacaine, lidocaine, and mepivacaine on voltage-gated Na+ and K+ currents in the membranes of these neurons. The patch-clamp technique was applied to intact dorsal horn neurons from laminae I-III identified in 200-microm slices of spinal cord from newborn rats. Under voltage-clamp conditions, the whole-cell Na+ and K+ currents activated by depolarization were recorded in the presence of different concentrations of local anesthetics. Externally applied bupivacaine, lidocaine, and mepivacaine produced tonic block of Na+ currents with different potencies. Half-maximum inhibiting concentrations (IC50) were 26, 112, and 324 microM, respectively. All local anesthetics investigated also showed a phasic, that is, a use-dependent, block of Na+ channels. Rapidly inactivating K+ currents (KA currents) also were sensitive to the blockers with IC50 values for tonic blocks o...Continue Reading

References

Apr 1, 1977·The Journal of General Physiology·B Hille
Jan 1, 1991·Annals of the New York Academy of Sciences·X T GuoG R Strichartz
Apr 1, 1990·Anesthesiology·J F Butterworth, G R Strichartz
Aug 1, 1990·Anesthesia and Analgesia·M Tabatabai, A M Booth
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P JonasW Vogel
Sep 1, 1989·Pflügers Archiv : European journal of physiology·F A EdwardsT Takahashi
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Aug 15, 1995·The Journal of Physiology·B V Safronov, W Vogel
Apr 1, 1995·The Journal of General Physiology·M E BräuW Vogel
Jan 1, 1993·The Journal of Physiology·B V SafronovW Vogel

❮ Previous
Next ❯

Citations

Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Rolf GöggelStefan Uhlig
Jun 19, 2009·Anesthesia and Analgesia·Andrea OlschewskiMatthias Wolff
Jun 22, 2000·Anesthesiology·S A IsaacsonJ Yang
Jun 5, 2001·Anesthesiology·S S Liu, S B McDonald
Apr 17, 2004·Anesthesiology·Matthias WolffGunter Hempelmann
Nov 28, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jennifer KankelBarbara Namer
Jun 29, 2010·Brain Research·Yoshihisa NakahataHitoshi Ishibashi
Aug 2, 2003·British Journal of Pharmacology·Ulrike BischoffAndrea Olschewski
Jan 13, 2016·Anesthesia and Analgesia·Tao HuTao Liu
Feb 17, 2005·Minerva anestesiologica·H A McLure, A P Rubin
Dec 25, 2009·Anesthesiology·Kenta FurutaniTatsuro Kohno
Mar 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christoph H KindlerC Spencer Yost

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.