Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications.

Experimental Biology and Medicine
Ian S ZagonPatricia J McLaughlin

Abstract

The opioid growth factor (OGF)-OGF receptor (OGFr) pathway is present in the ocular surface and functions to maintain homeostasis of the epithelium. The OGF-OGFr pathway has been reported to be dysregulated in diabetic individuals and animal models, and is reflected in elevations of the inhibitory growth factor, OGF, chemically termed [Met5]-enkephalin. Recently, our laboratory reported elevated levels of OGF and OGFr in the serum and corneal epithelium of type 1 diabetic rats, suggesting that dysregulation of the OGF-OGFr axis may lead to dry eye, abnormal corneal surface sensitivity, and delayed re-epithelialization. Blockade of OGF-OGFr pathway using naltrexone, a potent opioid receptor antagonist, reverses dry eye symptoms and restores corneal surface sensitivity in diabetic rats when used as a therapy. Based on the evidence that both OGF and OGFr are elevated in type 1 diabetic rats, this study examined whether systemic or topical naltrexone treatment initiated at the time of induction of hyperglycemia could protect against the development of diabetic ocular surface complications. Diabetic male Sprague-Dawley rats treated systemically or topically with naltrexone had a delayed onset of dry eye and altered corneal surface s...Continue Reading

References

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Nov 2, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ian S ZagonPatricia J McLaughlin
Apr 21, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Matthew S KlocekIan S Zagon
Oct 31, 2007·Journal of Diabetes and Its Complications·Pippa CousenBal Dhillon
Oct 27, 2009·Brain Research Bulletin·I S ZagonPatricia J McLaughlin
Nov 11, 2009·Archives of Ophthalmology·Ian S ZagonPatricia J McLaughlin
Jul 1, 2011·Investigative Ophthalmology & Visual Science·Jia YinFu-Shin X Yu
Jun 20, 2013·Clinical & Experimental Ophthalmology·Ian S ZagonPatricia J McLaughlin
Dec 18, 2013·Investigative Ophthalmology & Visual Science·Gerard A Lutty
Jul 22, 2015·Progress in Retinal and Eye Research·Alexander V Ljubimov, Mehrnoosh Saghizadeh
Apr 14, 2017·Vision Research·Alexander V Ljubimov
Jan 30, 2019·BMC Ophthalmology·Patricia J McLaughlinIan S Zagon

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Citations

Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Apr 28, 2021·Physiology & Behavior·Indira PurushothamanPatricia J McLaughlin
Jul 30, 2021·Biochemical Pharmacology·Indira PurushothamanPatricia J McLaughlin

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Methods Mentioned

BETA
confocal microscopy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Image J
ImageJ
GraphPad Prism

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