PMID: 8979043Dec 1, 1996Paper

Blockade of opioid-induced changes in auditory function at the level of the cochlea

Ear and Hearing
T L SahleyF E Musiek

Abstract

We have previously investigated the auditory neural effects of the kappa-opioid receptor agonist, (-)pentazocine. When administered intravenously (i.v.), this drug temporarily alters auditory nerve compound action potential (CAP) amplitudes. To test the hypothesis that the observed neural effects of i.v. (-)pentazocine occur via kappa-receptor interactions within the cochlea, we attempted to block these effects by employing a specific kappa-opioid receptor antagonist applied directly to the cochlear round window (RW) membrane. In 31 normal-hearing, male pigmented chinchillas, amplitude changes in the click-evoked auditory CAP (N1) were tracked at six stimulus intensities during a baseline and a postbaseline period in which i.v. (-)pentazocine (8 mg/kg) was administered. (-)Pentazocine administration was preceded by the delivery to the cochlear RW membrane of an artificial perilymph solution given alone or containing the kappa-opioid receptor selective antagonist, norbinaltorphimine (Nor-BNI), which was administered at two concentrations in separate groups of animals. The amplitude increase in the CAP after (-)pentazocine was significantly reduced when i.v. (-)pentazocine was preceded by RW-administered Nor-BNI (4 mM). The rever...Continue Reading

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Citations

Feb 27, 2001·Hearing Research·T L Sahley, R H Nodar
Jul 5, 2006·The European Journal of Neuroscience·Nopporn JongkamonwiwatPiyarat Govitrapong
Nov 15, 2011·Otolaryngologia polska. The Polish otolaryngology·Elżbieta WłodarczykAdam Piłka
Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Colleen G Le PrellSanford C Bledsoe

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