Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.

Nature Medicine
Yan WangHoward B Gutstein

Abstract

For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats. PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain.

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Citations

Sep 3, 2013·Neuroscience Letters·Simon Beggs, Michael W Salter
Oct 16, 2013·Peptides·Richard J Bodnar
Jan 8, 2013·Nature Neuroscience·Francesco FerriniYves De Koninck
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Aug 8, 2020·Frontiers in Neural Circuits·Yi ShenMarie-Eve Paquet
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Jun 1, 2021·Frontiers in Pharmacology·Jazlyn P BorgesBenjamin E Steinberg

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