Blockade of phosphodiesterase 4 reverses morphine-induced ventilatory disturbance without loss of analgesia

Life Sciences
Satoko KimuraA Haji

Abstract

Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in the respiratory-related neurons. Therefore, we examined the effects of caffeine, a methylxanthine non-selective phosphodiesterase (PDE) inhibitor with adenosine antagonistic activity, and rolipram, a racetam selective PDE4 inhibitor, on ventilatory depression induced by morphine. Spontaneous ventilation and paw withdrawal responses to nociceptive thermal stimulation were measured in anesthetized rats simultaneously. The efferent discharge of the phrenic nerve was recorded in anesthetized, vagotomized, paralyzed and artificially ventilated rats. Rolipram (0.1 and 0.3 mg/kg, i.v.) and caffeine (3.0 and 10.0 mg/kg, i.v.) relieved morphine (1.0 mg/kg, i.v.)-induced ventilatory depression but had no discernible effect on its analgesic action. Rolipram (0.3 and 1.0 mg/kg, i.v.) and caffeine (10.0 and 20.0 mg/kg, i.v.) recovered morphine (3.0 mg/kg, i.v.)-induced prolongation and flattening of inspiratory discharge in the phrenic nerv...Continue Reading

References

Oct 1, 1977·Life Sciences·A AldridgeA H Neims
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·D NicholsonJ Sawynok
Oct 1, 1990·The American Review of Respiratory Disease·J E ShookE M Camporesi
May 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·W Krause, G Kühne
Feb 24, 1993·Biochemical Pharmacology·D UkenaG W Sybrecht
Mar 1, 1994·Respiration Physiology·P PianosiJ V Aranda
Jan 1, 1997·Psychopharmacology·L L HowellR D Spealman
Sep 2, 1998·Progress in Neurobiology·W M St-John
Jul 7, 2000·Pharmacology & Therapeutics·A HajiM Okazaki
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 6, 2003·Progress in Neurobiology·Jana Sawynok, Xue Jun Liu
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley
Dec 24, 2005·Critical Reviews in Food Science and Nutrition·Faidon Magkos, Stavros A Kavouras
Apr 9, 2008·Respiratory Physiology & Neurobiology·Peter M Lalley
May 6, 2008·British Journal of Anaesthesia·K T S Pattinson
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jeffrey C SmithJulian F R Paton
Dec 17, 2009·Anesthesiology·Albert DahanTerry W Smith
May 7, 2010·Respiratory Physiology & Neurobiology·Araya Ruangkittisakul, Klaus Ballanyi
Jun 26, 2013·Respiratory Physiology & Neurobiology·Francis J GolderJames F McLeod
Sep 3, 2013·European Journal of Pharmacology·Satoko Kimura, Akira Haji
Oct 25, 2014·F1000prime Reports·Rutger van der SchierMarieke Niesters

❮ Previous
Next ❯

Citations

Mar 30, 2016·Journal of Pharmacological Sciences·Satoko KimuraAkira Haji
Apr 4, 2016·European Journal of Pharmacology·Akira HajiYoshiaki Ohi
Mar 20, 2018·Anesthesiology·Albert DahanMarieke Niesters
Oct 5, 2017·Frontiers in Biology·Christopher M Olsen, Qing-Song Liu
Apr 8, 2021·Journal of Neurophysiology·Jan-Marino RamirezErica S Levitt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.