Blockade of progesterone-activated estrous behavior in rats by intracerebral anisomycin is site specific

Neuroendocrinology
J H Glaser, R J Barfield

Abstract

The hypothesis that progesterone (P) activates estrous behavior in estrogen-primed female rats via a protein synthetic mechanism was examined. The protein synthesis inhibitor anisomycin was applied intracerebrally via 28-gauge bilateral implants to neural sites implicated in the mediation of estrous responsiveness. Results showed that anisomycin blockade of P-activated estrous behavior was neural site specific. Animals with anisomycin placed in the ventromedial hypothalamus (VMH) (n = 27) showed low levels of lordosis and solicitation behavior 4 h after the subcutaneous administration of 500 micrograms P, whereas animals with anisomycin implants in the preoptic area (n = 11) or the midbrain area in the region of the interpeduncular nucleus (n = 11) displayed high levels of estrous behavior. No deficits in open-field activity were observed following localized anisomycin treatment, and all animals appeared to be healthy. Results of the present study are consistent with the hypothesis that P acts to promote estrous behavior via a receptor-mediated genomic protein synthetic mechanism, and provide additional evidence that the VMH is the primary site of P action.

Citations

Jan 1, 1987·Physiology & Behavior·I U VathyR J Barfield
Apr 1, 1991·Physiology & Behavior·C A Lisciotto, J F DeBold
Jan 1, 1984·Psychoneuroendocrinology·R J BarfieldA M Etgen
Feb 1, 1984·Brain Research Bulletin·R L Meisel, D W Pfaff
Oct 1, 1988·Brain Research Bulletin·E T Pleim, J F DeBold
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C J KrebsD W Pfaff
Dec 1, 1989·Hormones and Behavior·M S Erskine
Jan 1, 1986·Annals of the New York Academy of Sciences·C Beyer, G González-Mariscal

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