Blockade of serotonin-2C receptors by mesulergine reduces ocular dominance plasticity in kitten visual cortex

Experimental Brain Research
Y WangM S Cynader

Abstract

We have investigated the role of serotonin-2C (5-HT2C) receptors in modulation of ocular dominance plasticity in kitten visual cortex. A small quantity of the 5-HT2C receptor blocker, mesulergine, was infused into the visual cortex of one hemisphere of 5- to 7-week-old kittens using osmotic minipumps, while the control hemisphere received vehicle solution. At the same time, one eyelid of the experimental animals was sutured shut. The ocular dominance distributions in the visual cortex (area 17) were assessed using extracellular recording methods after 1 week of combined mesulergine infusion and monocular deprivation. We found that the majority of the neurons remained binocularly responsive in the mesulergine-treated hemisphere, while most of the neurons recorded were either unresponsive or only weakly responsive to the deprived eye in the control hemisphere. Local infusion of mesulergine into the kitten visual cortex thus reduced the shift of ocular dominance that normally occurs in animals of these ages following monocular deprivation. The blocking effect seems to be distance-dependent and therefore dose-dependent: the farther away the recording sites were from the injection site, the fewer binocularly responsive cells were fo...Continue Reading

Citations

Mar 30, 1999·Brain Research·E F BastosC A Serfaty
Dec 13, 2000·Brain Research. Brain Research Reviews·D O Frost, J L Cadet
Mar 15, 2001·Brain Research. Developmental Brain Research·L KojicM S Cynader
Jul 18, 1997·Brain Research. Developmental Brain Research·L KojicM S Cynader
Aug 13, 2013·Neural Plasticity·Ettore TiraboschiEero Castrén
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·L KojicM S Cynader
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Kirkwood
Jul 6, 2010·Journal of Chemical Neuroanatomy·Karolina Rogozinska, Jolanta Skangiel-Kramska
Apr 9, 2008·Experimental Neurology·Ericka M C GonzálezClaudio Alberto Serfaty
Dec 16, 2010·The European Journal of Neuroscience·José Fernando Maya VetencourtLamberto Maffei
Aug 2, 2012·Neural Plasticity·José Fernando Maya-Vetencourt, Nicola Origlia
May 7, 2009·Experimental Neurology·Letícia Abel PenedoClaudio Alberto Serfaty
Sep 30, 1999·Journal of Neurobiology·M F Bear, C D Rittenhouse
Mar 15, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung-Won ParkDuck-Joo Rhie
Nov 12, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kayoung JooHyun-Jong Jang
Nov 18, 2003·Nature Reviews. Neuroscience·Patricia GasparLuc Maroteaux
Jun 8, 2017·Frontiers in Cellular Neuroscience·Anne TeissierPatricia Gaspar
Aug 2, 2020·The Journal of Comparative Neurology·Takuji Kasamatsu, Kazuyuki Imamura
Sep 1, 2020·PLoS Genetics·Maureen M SampsonDavid E Krantz
Oct 28, 2017·Frontiers in Endocrinology·Maria C Tickerhoof, Adam S Smith
Sep 27, 2001·The Journal of Biological Chemistry·R D PriceE Sanders-Bush

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.