Blockade of spreading depression in chronic epileptic rats: reversion by diazepam

Epilepsy Research
R C Guedes, E A Cavalheiro

Abstract

Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week. The aim of this work was to verify the characteristics of spreading depression (SD) in these chronic epileptic rats (n = 16). SD was evoked in one point of the frontal cortex by topical application of KCl solution at 20 min intervals, and recordings were made in two points over the parietal cortex (a 'near' point and a 'remote' one, about 3 and 8 mm posterior to the stimulating region, respectively). In all control animals (n = 10), KCl stimulation elicited SD which in 100% of the cases propagated regularly to the two recording points. In the chronic epileptic rats only about 50% of the KCl applications were effective in eliciting SD, detected at the 'near' recording point. Of these, only 3% propagated to the 'remote' recording point. In eight of the above epileptic rats, diazepam (5-10 mg/kg, i.v.) was injected after 1-2 h of recording, when SD incidence in response to KCl stimulation has been established. After diazepam, the incidence of SDs propagating regularly to the 'near' and to the 'remote' recording points increased significantly, (132 and 53 SDs, respectively, out of 139 KCl stimulat...Continue Reading

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Citations

Jan 1, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cássia Borges LimaRubem Carlos Araujo Guedes
Mar 1, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Noranege Epifânio AcciolyRubem Carlos Araujo Guedes
Feb 24, 2005·Brain Research·Rubem Carlos Araújo GuedesNobuyoshi Matsumoto
Jan 17, 2013·Nutritional Neuroscience·Rubem Carlos Araújo GuedesElian da Silva Francisco
Nov 6, 2004·Nutritional Neuroscience·Carlos Augusto Carvalho De VasconcelosRubem Carlos Araújo Guedes
Nov 21, 2007·Nutritional Neuroscience·Katia Karina Do Monte-SilvaRubem Carlos Araújo Guedes
Jul 22, 2008·Neuroscience Letters·Rubem Carlos Araújo Guedes, Carlos Augusto Carvalho de Vasconcelos
Jul 23, 2013·Life Sciences·Cássia Borges LimaRubem Carlos Araújo Guedes
Mar 19, 2013·European Journal of Pharmacology·Angela Amancio-Dos-SantosRubem Carlos Araújo Guedes
Jul 16, 2011·Nutritional Neuroscience·Heloisa Mirelle Costa MonteiroRubem Carlos Araújo Guedes
Jul 29, 2017·Cephalalgia : an International Journal of Headache·Lyudmila V Vinogradova
Nov 12, 2009·Expert Review of Neurotherapeutics·Vinod Kumar Gupta
Jun 27, 1998·Current Opinion in Neurology·A A Parsons
Jun 25, 2019·Frontiers in Aging Neuroscience·Rubem Carlos Araújo Guedes, Ricardo Abadie-Guedes
Oct 18, 2019·Frontiers in Neuroscience·Elian da Silva FranciscoRubem Carlos Araújo Guedes
Dec 18, 2008·Neuroscience and Behavioral Physiology·V I KorolevaG Ya Roshchina
Apr 15, 2021·Nature Communications·Isra TamimCenk Ayata
Sep 21, 2018·Brain Research Bulletin·Rosângela Figueiredo Mendes-da-SilvaRubem Carlos Araújo Guedes
Jul 7, 2009·Experimental Neurology·Ana Paula Barbosa do AmaralRubem Carlos Araújo Guedes
Aug 20, 2021·Scientific Reports·Nancy N Ortiz-VillatoroCarla A Scorza

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