Blockade of synaptic inhibition within the pre-Bötzinger complex in the cat suppresses respiratory rhythm generation in vivo

The Journal of Physiology
O PierreficheD W Richter

Abstract

1. The role of synaptic inhibition in respiratory rhythm generation was analysed by microinjections of GABAA and glycine receptor antagonists into the bilateral pre-Botzinger complex (PBC) of anaesthetized cats. Central respiratory activity was monitored by phrenic nerve recordings. 2. Bilateral injections of bicuculline (50 or 100 microM) irreversibly slowed respiratory frequency and induced apneustic patterns. 3. Bilateral injections of strychnine (50 or 100 microM) greatly reduced phrenic burst amplitudes leading to increased burst frequency or irreversibly blocked rhythmic phrenic discharges. After unilateral tetrodotoxin (TTX) blockade in the PBC, strychnine injection into the contralateral PBC blocked rhythmic phrenic discharges. 4. Bilateral blockade of both GABAergic and glycinergic inhibition abolished rhythmic burst discharges and only tonic phrenic activity remained. Such tonic activity was blocked only by TTX (1 microM). 5. Potentiation of synaptic inhibition by the serotonin 1A receptor agonist 8-hydroxydipropylaminotetralin (8-OH-DPAT; 50 microM) restored rhythmic activity only when given shortly after strychnine and bicuculline applications. It was, however, ineffective after blockade of synaptic inhibition was c...Continue Reading

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Citations

Oct 17, 2002·Respiratory Physiology & Neurobiology·Uwe MarkstahlerDiethelm W Richter
Jan 4, 1998·Respiration Physiology·J M RamirezD W Richter
Jul 31, 2001·Trends in Neurosciences·D W Richter, K M Spyer
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Dec 18, 2001·Neuroscience Letters·D BüsselbergD W Richter
Jul 11, 2002·Respiratory Physiology & Neurobiology·Mathias Dutschmann, Julian F R Paton
Sep 5, 2002·Respiratory Physiology & Neurobiology·Walter M St-John, Julian F R Paton
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Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Till ManzkeDiethelm W Richter
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