Blockade of testosterone-induced mounting behavior in the male rat with intracranial application of the aromatization inhibitor, androst-1,4,6,-triene-3,17-dione

Endocrinology
L W Christensen, L G Clemens

Abstract

Propylene glycol (glycol) solutions containing either testosterone (T) or estradiol (E2) were infused directly into the preoptic area (POA) of longterm castrated rats in order to reinstate male copulatory behavior. In addition, castrated males were administered T or E2 in the POA in combination with a steroid that has been shown to block the aromatization of testosterone to estradiol, androst-1,4,6-triene-3,17-dione (ATD). The facilitatory action of testosterone on mounting behavior was blocked when it was given in combination with ATD. Animals treated in the POA with glycol +T, glycol +E2 or ATD + E2 all showed significant increases in mounting behavior over preimplant levels. There was no significant rise in the number of intromissions or ejaculations in any of the hypothesis that, at least for mounting behavior, aromatization is necessary for the stimulation of male sexual behavior by testosterone.

Citations

Jul 1, 1979·Journal of Steroid Biochemistry·A M BrodieH J Brodie
Jan 1, 1988·Physiology & Behavior·L G ClemensB Rakerd
Mar 1, 1980·Pharmacology, Biochemistry, and Behavior·C Fabre-Nys, J P Signoret
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·E M Kostarczyk
Oct 1, 1993·Brain Research. Molecular Brain Research·R H LustigH J Federoff
Jun 1, 1980·Molecular and Cellular Endocrinology·B S McEwen
Apr 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C E Roselli, T A Fasasi
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C E Roselli, J A Resko
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·A LaMorteK Sundaram
Mar 14, 2002·Physiology & Behavior·J ManzoP Pacheco
May 30, 2002·Neuroscience and Biobehavioral Reviews·Russell D RomeoCheryl L Sisk
Mar 4, 1998·Psychoneuroendocrinology·I Del Río-PortillaM Corsi-Cabrera
Jun 10, 2000·Journal of Neuroendocrinology·C E RoselliJ A Resko
Aug 1, 1994·Journal of Neuroendocrinology·U R Sharma, E F Rissman
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aurore L SeredynskiCharlotte A Cornil
Aug 31, 2000·Hormones and Behavior·A N ClancyR P Michael
Oct 1, 1979·Journal of Endocrinological Investigation·A M Brodie
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Takahiro MatsumotoNobuhiro Harada
Nov 22, 2011·Neuroscience Research·Hirotaka Sakamoto
Aug 14, 2003·Scandinavian Journal of Psychology·Raúl G Paredes
Aug 14, 2003·Scandinavian Journal of Psychology·Michael J Baum
Feb 20, 2009·Journal of Neuroendocrinology·N HaradaS-I Honda
Apr 1, 1978·Hormones and Behavior·P Yahr, S A Gerling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.