Blockade of the anxiolytic action of 8-OH-DPAT in lactating rats

Pharmacology, Biochemistry, and Behavior
A Fernández-GuastiA Ferreira

Abstract

The anxiolytic action of 8-OH-DPAT (0.125, 0.5, and 0.75 mg/kg, I.P., -15 min) was evaluated in ovariectomized and 7-day lactating mother rats. This serotonergic anxiolytic produces a clear reduction in cumulative burying behavior and in freezing time (parameters denoting a reduction in anxiety levels) in ovariectomized subjects. However, in 7-day lactating mother rats, 8-OH-DPAT lacked its antianxiety effects. Additionally, as an extra parameter of the animal's emotionality the number of defecation bolus was registered. A reduction in this parameter in ovariectomized animals after 8-OH-DPAT (0.5 mg/kg) injection was found. This effect was also blocked in 7-day lactating rats. None of the doses of the compound tested altered the burying behavior latency (a parameter inversely representing the animal's reactivity). The general ambulatory behavior of ovariectomized subjects was significantly impaired at the highest dose (0.75 mg/kg) of 8-OH-DPAT. Lower doses did not alter this parameter or the number of times lines are crossed (a parameter denoting exploratory activity). Discussion is focused on the relationship between the activity of the serotonergic system and the secretion of prolactin in this period.

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Citations

Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·A FerreiraA Fernández-Guasti
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·A Fernández-GuastiO Picazo
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Joseph S Lonstein, Stephen C Gammie
Dec 24, 1997·Behavioural Brain Research·A Fernández-Guasti, O Picazo
Jul 6, 2010·Pharmacology, Biochemistry, and Behavior·R M CraftK T Tsutsui
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Aug 20, 2011·Pharmacology, Biochemistry, and Behavior·Stephanie M MillerJoseph S Lonstein
Dec 8, 2004·Physiology & Behavior·Erin C Stoffel, Rebecca M Craft
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·M A AguinagaJ F Aguilera

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