Blockade of the classical pathway of protein secretion does not affect the cellular exportation of lipocortin 1

Regulatory Peptides
J G PhilipJulia Buckingham

Abstract

The mechanism by which lipocortin 1 (LC1) is extruded from cells in the brain and periphery in response to a glucocorticoid challenge is unknown. This study examined the influence of three inhibitors of the classical endoplasmic reticulum-Golgi pathway of protein secretion on the dexamethasone-induced (0.1 microM, 2-3 h) cellular exportation of LC1 in vitro in brain (cortex, hippocampus, hypothalamus), anterior pituitary tissue and peritoneal macrophages. In all instances, the steroid-induced exportation of LC1 was unaffected by brefeldin A (1.4 microM), monensin (10 microM) and nocodazole (3.3 microM); however, these drugs readily blocked the release of corticotrophin from pituitary tissue. These data suggest that LC1 is exported by a mechanism distinct from the classical pathway of protein secretion.

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Citations

Apr 25, 2012·Cell and Tissue Research·Kristian PrydzJaakko Saraste
Mar 30, 2004·Trends in Endocrinology and Metabolism : TEM·Christopher D JohnJulia C Buckingham
Feb 15, 2003·European Journal of Pharmacology·Rebecca H RitchieGregory J Dusting
May 25, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E SolitoJ C Buckingham
Oct 9, 2004·Inflammatory Bowel Diseases·Nathalie VergnolleChristine Coméra
Jul 25, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·A Mulla, J C Buckingham
Mar 13, 2008·Biochimica Et Biophysica Acta·Hugo O van GenderenChris P M Reutelingsperger
Oct 11, 2008·Current Opinion in Pharmacology·Christopher D JohnJulia C Buckingham
Aug 12, 2003·Cell Biochemistry and Function·Julia C BuckinghamJohn Morris
Mar 28, 2002·Physiological Reviews·Volker Gerke, Stephen E Moss
Oct 26, 2002·Endocrinology·Lee ChapmanHelen C Christian
Jan 16, 2016·Clinical Science·Zied BoudhraaFrançoise Degoul
Apr 5, 2018·International Journal of Molecular Sciences·Madeeha H Sheikh, Egle Solito
Jan 10, 2013·PloS One·Sarah E MercerHans-Georg Simon

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