Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382

Physiology & Behavior
G ColomboG L Gessa

Abstract

The present study was designed to assess the ability of the newly synthetized, selective gamma-hydroxybutyric acid (GHB) receptor antagonist, NCS-382, in blocking the discriminative stimulus effects of GHB in a T-maze, food-reinforced drug discrimination procedure. Two groups of rats were trained to run the left arm of the maze 30 min after the i.g. administration of either 300 or 700 mg/kg GHB and the right arm after water. Once discrimination was acquired, combination of different doses of NCS-382 (0, 12.5, 25.0 and 50.0 mg/kg, IP) and GHB training doses were tested for blockade of GHB discrimination. NCS-382 dose-dependently blocked GHB-appropriate responding in both the 300 and 700 mg/kg GHB rat groups. The results of the present study indicate that the discriminative stimulus properties of GHB are mediated via stimulation of GHB receptors.

References

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Citations

Aug 1, 1996·Journal of Neuroscience Methods·G ColomboG L Gessa
Jun 12, 2003·European Journal of Pharmacology·Richard J LambCharles P France
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·B R MetcalfP L Soto
Apr 12, 2001·Drug and Alcohol Dependence·K L Nicholson, R L Balster
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nathan AbsalomPetrine Wellendorph
Jul 31, 2001·Journal of Psychoactive Drugs·C H McDaniel, K A Miotto
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant
Nov 18, 2008·Pharmacology & Therapeutics·Lawrence P CarterCharles P France
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lawrence P CarterCharles P France
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lawrence P CarterCharles P France
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Huifang WuAndrew Coop
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekCharles P France
Jul 10, 2002·Annals of the New York Academy of Sciences·Yossef Itzhak, Syed F Ali
Mar 19, 2005·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekCharles P France
Dec 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Wouter KoekCharles P France

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