Blockade of the dopamine receptor: a possible mechanism of action of antipsychotic drugs (author's transl)

Pharmakopsychiatrie, Neuro-Psychopharmakologie
M Karobath

Abstract

Antipsychotic drugs of various types inhibit dopamine-sensitive adenylate cyclase (EC 4.6.1.1) while structurally related drugs that were not clinically effective as antipsychotic drugs were almost inactive. These results are discussed in relation to the suggestion that antipsychotic activity may be related to the blockade of dopamine receptors in the brain.

Citations

Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·F Z MeersonE E Ustinova

Related Concepts

Adenylate Cyclase
Brain
Intropin
Receptors, Drug
Tranquilizing Effect

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