Blockade of the dorsomedial hypothalamus and the perifornical area inhibits respiratory responses to arousing and stressful stimuli

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
E BondarenkoEugene Nalivaiko

Abstract

The dorsomedial hypothalamus (DMH) and the perifornical area (DMH/PeF) is one of the key regions of central autonomic processing. Previous studies have established that this region contains neurons that may be involved in respiratory processing; however, this has never been tested in conscious animals. The aim of our study was to investigate the involvement of the DMH/PeF area in mediating respiratory responses to stressors of various intensities and duration. Adult male Wistar rats (n = 8) received microinjections of GABAA agonist muscimol or saline into the DMH/PeF bilaterally and were subjected to a respiratory recording using whole body plethysmography. Presentation of acoustic stimuli (500-ms white noise) evoked transient responses in respiratory rate, proportional to the stimulus intensity, ranging from +44 ± 27 to +329 ± 31 cycles/min (cpm). Blockade of the DMH/PeF almost completely abolished respiratory rate and tidal volume responses to the 40- to 70-dB stimuli and also significantly attenuated responses to the 80- to 90-dB stimuli. Also, it significantly attenuated respiratory rate during the acclimatization period (novel environment stress). The light stimulus (30-s 2,000 lux) as well as 15-min restraint stress signi...Continue Reading

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Citations

Nov 22, 2015·Respiratory Physiology & Neurobiology·Tabinda ZafarCaroline Sévoz-Couche
Jun 5, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger A L Dampney
Jul 23, 2016·Advances in Physiology Education·Roger A L Dampney
May 27, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charly BrouillardCaroline Sévoz-Couche
Jan 20, 2021·Fundamental & Clinical Pharmacology·Michelle M MendonçaCarlos Henrique Xavier
Jan 12, 2021·Journal of Neurophysiology·Thiago S MoreiraAna C Takakura
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Aska UjitaVitor R G Mercadante

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