Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans

The American Journal of Physiology
J MøllerJ S Christiansen

Abstract

To test if the renin-angiotensin-aldosterone system (RAAS) is involved in growth hormone (GH)-associated fluid retention, we examined the effect of GH administration in the presence or absence of RAAS blockade at different levels on body fluid homeostasis. Eight subjects were examined in a controlled, randomized double-blinded trial. During four 6-day periods they received subcutaneous GH (6 IU-m-2) or placebo injections and tablets as follows: 1) placebo and placebo, 2) GH and placebo, 3) GH and captopril, and 4) GH and spironolactone. GH increased extracellular volume (liters; placebo 18.87 +/- 0.85; GH + placebo 20.43 +/- 1.01) but this effect was abolished by captopril (GH + captopril 18.82 +/- 0.67) and spironolactone (GH + spironolactone 18.99 +/- 0.85). Correspondingly, the GH-induced reduction in bioimpedance was blocked by captopril and spironolactone. Plasma renin and angiotensin II concentrations increased during all three GH treatment regimens, whereas plasma aldosterone was increased only after GH plus spironolactone. The data demonstrate that GH activates the RAAS and that blockade of the RAAS by two separate mechanisms prevents fluid retention normally encountered after GH exposure. These observations suggest tha...Continue Reading

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Citations

Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·K H LangeM Kjaer
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·T K HansenJ S Christiansen
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M C KammerlB K Krämer
Jun 26, 2003·American Journal of Physiology. Renal Physiology·Ka-Yin K MokSusan E Mulroney
May 3, 2018·European Journal of Endocrinology·Jens O L Jørgensen, Anders Juul
Oct 26, 2006·American Journal of Physiology. Renal Physiology·Henrik DimkeSebastian Frische
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner

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