Blockade of vascular ATP-sensitive potassium channels reduces the vasodilator response to ischaemia in humans

Diabetologia
P J BijlstraP Smits

Abstract

Experimental data show that ATP-sensitive potassium (KATP) channels not only occur in pancreatic beta cells, but also in the cardiovascular system, where they mediate important cardioprotective mechanisms. Sulphonylurea derivatives can block the cardiovascular KATP channels and may therefore interfere with these cardioprotective mechanisms. Therefore, it is of clinical importance to investigate whether sulphonylurea derivatives interact with vascular KATP channels in humans. Using venous-occlusion strain-gauge plethysmography, we investigated whether ischaemia-induced reactive hyperaemia is reduced by the sulphonylurea derivative glibenclamide in 12 healthy male non-smoking volunteers. Forearm vasodilator responses to three periods of arterial occlusion (2, 5 and 13 min) during concomitant infusion of placebo into the brachial artery were compared with responses during concomitant intra-arterial infusion of glibenclamide (0.33 microgram.min-1.dl-1). A control study (n = 6) showed that time itself did not change the vasodilator response to ischaemia. Glibenclamide significantly increased minimal vascular resistance (from 2.1 +/- 0.1 to 2.3 +/- 0.2 arbitrary units, Student's t-test: p = 0.01), and reduced mean forearm blood flow ...Continue Reading

Citations

Mar 16, 2002·European Journal of Clinical Investigation·E J AbbinkP Smits
Mar 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·E J AbbinkP Smits
Aug 19, 2007·Coronary Artery Disease·Maria BilinskaRyszard Piotrowicz
Jan 5, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J J MonsuezE Vicaut
Mar 14, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Faisel KhanAleksandar Jovanović
Oct 4, 2005·Current Medical Research and Opinion·Ewoud ter AvestAnton F H Stalenhoef
Mar 1, 2012·European Journal of Pharmacology·Richard EngbersenFrans G M Russel
Nov 26, 2015·Respiratory Physiology & Neurobiology·Clark T HoldsworthTimothy I Musch
Mar 12, 2015·Journal of Clinical Biochemistry and Nutrition·Shigeru ShimadaMasaichi-Chang-Il Lee
Aug 7, 2007·Microvascular Research·Ksenija Cankar, Martin Strucl
Jun 12, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·John PaliosDimitrios Kremastinos
Oct 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Heidi J RobertshawGeorge H Hall
Aug 6, 2000·British Journal of Anaesthesia·G R McAnultyG M Hall
Jun 22, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Claire GobronHugues Chabriat
Aug 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Aaron H BubolzYanping Liu
Mar 31, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Clark T HoldsworthTimothy I Musch
Jan 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·H M Omar Farouque, Ian T Meredith
Oct 8, 2009·Diabetes·Pia ThaningJaya B Rosenmeier
Jul 29, 2004·Journal of Endocrinological Investigation·P SpallarossaC Brunelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Risk Reduction

Prevention of cardiovascular disease is an important health initiative. Risk reduction including physical activity, smoking cessation, diet, blood pressure lowering drugs and pharmacotherapy. Here is the latest research on cardiovascular risk reduction.