PMID: 6992175Jan 1, 1980Paper

Blockade of vasoconstrictor responses by prostacyclin (PGI2), PGE2, and PGE1 in the rabbit hindquarters vascular bed

Prostaglandins and Medicine
A L GottliebP J Kadowitz

Abstract

The effects of infusions of prostacyclin (PGI2), PGE2 and PGE1 on responses to pressor hormones and sympathetic nerve stimulation were investigated in the hindquarters vascular bed of the rabbit. During infusions of PGI2, PGE2 and PGE1 vasoconstrictor responses to norepinephrine, nerve stimulation and angiotensin II were decreased. Responses to the pressor hormones and nerve stimulation were decreased to a similar extent by PGI2 and responses returned to control value 30 min after the infusion. During infusions of PGE2 and PGE1 responses to nerve stimulation were decreased to a somewhat greater extent than responses to pressor hormones and the inhibitory action of these substances had a longer duration of action than PGI2. Indomethacin in doses that blocked depressor responses to arachidonic acid was without consistent effect on responses to nerve stimulation and pressor hormones. The present data show that E series prostaglandins and PGI2 possess the ability to modulate responses to nerve stimulation and pressor hormones; however, experiments with indomethacin suggest that endogenous prostaglandins do not modulate vasoconstrictor responses in the rabbit hindquarters.

References

Jul 28, 1978·Biochemical and Biophysical Research Communications·P Y WongK U Malik
Sep 1, 1979·Circulation Research·A L Hyman, P J Kadowitz
Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Feb 1, 1978·Circulation Research·T M FitzpatrickP A Kot
Oct 1, 1978·British Journal of Pharmacology·G J DustingJ R Vane

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Citations

Sep 1, 1989·The Journal of Surgical Research·J V SitzmannP W Lin
Jul 5, 1996·International Journal of Cardiology·Y AbeY Maruyama
Oct 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H L LipptonP J Kadowitz
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Moon-Hyon Hwang, Sangho Kim
Jun 4, 2002·The Journal of Physiology·Stephen B RublePhilip S Clifford
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P HadházyK Magyar
May 1, 1981·Prostaglandins and Medicine·E G PontecorvoP J Kadowitz
Oct 1, 1989·Circulation Research·J A LopezD D Heistad

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