PMID: 11899428Mar 20, 2002Paper

Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis

Immunology
D S BardensteinM E Medof

Abstract

The open environment of the eye is continuously subject to an influx of foreign agents that can activate complement. Decay-accelerating factor (DAF), membrane cofactor protein (MCP) and CD59 are regulators that protect self-cells from autologous complement activation on their surfaces. They are expressed in the eye at unusually high levels but their physiological importance in this site is unstudied. In the rat, a structural analogue termed 5I2 antigen (5I2 Ag) has actions overlapping DAF and MCP. In this investigation, we injected F(ab')2 fragments of 5I2 mAb into the conjunctiva and aqueous humor, in the latter case with and without concomitant blockage of CD59. Massive neutrophilic infiltration of the stroma and iris resulted upon blocking 5I2 Ag activity. Frank necrosis of the iris occurred upon concomitant intraocular blockage of CD59. C3b was identified immunohistochemically, and minimal effects were seen in complement-depleted animals and in those treated with non-relevant antibody. The finding that blockage of 5I2 Ag function in periocular tissues and within the eye causes intense conjunctival inflammation and iritis demonstrates the importance of intrinsic complement regulators in protecting ocular tissues from spontan...Continue Reading

References

Apr 1, 1977·American Journal of Ophthalmology·B J MondinoS I Brown
Sep 1, 1991·Immunology Today·P J Lachmann
Jan 1, 1986·The Journal of Experimental Medicine·A S AschV Nussenzweig
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M M LedermanM E Medof
Jul 1, 1989·Kidney International·F G CosioN S Nahman
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M E MedofV Nussenzweig
Nov 1, 1985·Archives of Ophthalmology·A D ProiaF P Sanfilippo
Jan 1, 1971·Annals of Internal Medicine·A D Steinberg, N Talal
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M K PangburnH J Müller-Eberhard
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Nicholson-WellerK F Austen
Nov 1, 1980·Archives of Ophthalmology·B J Mondino, D B Hoffman
Aug 1, 1981·Archives of Ophthalmology·B J Mondino, K J Brady
Dec 1, 1981·European Journal of Immunology·M S Neuberger, K Rajewsky
Oct 1, 1994·Clinical Immunology and Immunopathology·G KahalyH P Dienes
Oct 1, 1993·Transfusion·R YomtovianM E Medof

❮ Previous
Next ❯

Citations

Nov 26, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tomohiro MizunoYasuhiko Ito
Sep 20, 2005·Genome Biology·Jennifer J DiehnPatrick O Brown
Jul 19, 2005·Expert Opinion on Investigational Drugs·Masashi Mizuno, Duncan S Cole
Oct 17, 2003·Current Eye Research·Catherine BlondinChristophe Baudouin
Aug 10, 2007·American Journal of Ophthalmology·Liem TrinhChristophe Baudouin
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Sep 16, 2006·Immunological Reviews·Rachel R Caspi
Jan 31, 2006·Brain Research Reviews·Scott R Barnum, Alexander J Szalai
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Purushottam JhaNalini S Bora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved