Abstract
Dopamine (DA) has, as of late, become singled out from the profusion of other neurotransmitters as what could be called a key substance, in the regulation of the sleep-wake states. We have hypothesized that dopaminergic D(2) receptor blockage induced by haloperidol could generate a reduction or even an ablation of rapid eye movement (REM) sleep. Otherwise, the use of the selective D(2) agonist, piribedil, could potentiate REM sleep. Electrophysiological findings demonstrate that D(2) blockage produced a dramatic reduction of REM sleep during the rebound (REB) period after 96 h of REM sleep deprivation (RSD). This reduction of REM sleep was accompanied by an increment in SWS, which is possibly accounted for the observed increase in the sleep efficiency. Conversely, our findings also demonstrate that the administration of piribedil did not generate additional increase of REM sleep. Additionally, D(2) receptors were found down-regulated, in the haloperidol group, after RSD, and subsequently up-regulated after REB group, contrasting to the D(1) down-regulation at the same period. In this sense, the current data indicate a participation of the D(2) receptor for REM sleep regulation and consequently in the REM sleep/SWS balance. Here...Continue Reading
Citations
Aug 29, 2012·Clinical Psychology Review·Benjamin S McKenna, Lisa T Eyler
Sep 10, 2013·Neuropharmacology·Mariana B ProençaMarcelo M S Lima
Mar 14, 2013·Sleep Medicine Reviews·Marcelo M S Lima
May 19, 2011·Clinical Neuropharmacology·Aurore GouraudUNKNOWN French Association of Regional Pharmacovigilance Centres
Mar 3, 2015·Expert Opinion on Therapeutic Targets·Frank BellivierJan Scott
Oct 9, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo Maria Rossini
Apr 28, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Adriano ZagerSergio Tufik
Nov 11, 2008·Brain Research·Monica L AndersenSergio Tufik
Aug 18, 2010·Bipolar Disorders·Greg Murray, Allison Harvey
Aug 3, 2013·Journal of Neuroscience Research·Ana Carolina D Dos SantosMarcelo M S Lima
Aug 11, 2012·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Hong LvBing Yao
Dec 7, 2013·Neuroscience Letters·Nian YangJun Zhang
May 18, 2010·Clinical Psychology Review·Allison G HarveyAdriane Soehner
Apr 20, 2016·Neuropharmacology·Adriano D S TargaMarcelo M S Lima
Nov 12, 2013·Neurobiology of Disease·Carole HyacintheImad Ghorayeb
Mar 18, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A S C FrançaS Ribeiro
Sep 15, 2014·Behavioural Brain Research·Ana Carolina D NosedaMarcelo M S Lima
Jan 13, 2015·Annual Review of Clinical Psychology·Lauren B AlloyElaine M Boland
Sep 29, 2009·Behavioural Brain Research·Takayuki IshidaChiaki Kamei
Feb 25, 2015·Molecular Neurobiology·Dabna H TomimLuana Fischer
Dec 19, 2014·Frontiers in Cellular Neuroscience·Lais S RodriguesMarcelo M S Lima
May 16, 2014·Molecular Neurobiology·Maira J MaturanaMarcelo M S Lima
Sep 24, 2016·Molecular Neurobiology·Patrícia Dos SantosMarcelo M S Lima
Nov 28, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C A SantosS Tufik
Jun 26, 2018·Chronobiology International·Julia MaruaniPierre A Geoffroy
Sep 18, 2018·Behavioural Pharmacology·Lais S RodriguesMarcelo M S Lima
Feb 15, 2019·Scientific Reports·Juliane FagottiMarcelo M S Lima
Sep 1, 2020·Journal of Sleep Research·Gustavo Zampier Dos Santos LimaMarcelo M S Lima
Mar 16, 2019·Frontiers in Neuroscience·Jelena CiricJasna Saponjic
Feb 24, 2010·Sleep·R C S MartinsS Tufik