Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB

Biochemical and Biophysical Research Communications
Marie YeoKi-baik Hahm

Abstract

Helicobacter pylori infection leads to significant inflammations in the gastric mucosa, which is closely associated with development of gastric cancer. Heat shock protein 90 (HSP 90) has been revealed to be critical for intracellular signaling that participates in inflammatory response as well as carcinogenesis. In this study, we investigated a regulatory role of HSP 90 in H. pylori-induced IL-8 production. Our results showed that H. pylori stimulated significant phosphorylation of HSP 90 and the phosphorylation was diminished by administration of HSP 90 inhibitor, geldanamycin (GA). Treatment of GA completely inhibited H. pylori-induced IL-8 production due to deactivation of ERK1/2 and NF-kappaB. These results subsequently lead to inactivation of AP-1 and NF-kappaB, which are known to be major transcriptional factors of IL-8. Our data provide important insights that HSP 90 is involved as a crucial regulator in H. pylori-induced IL-8 production and its inhibitor could be potentially used for the inhibition of H. pylori-provoked inflammation.

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Citations

Aug 29, 2007·Infection and Immunity·Koh TomimoriNaoki Mori
Jun 23, 2006·Infection and Immunity·Brian HendersonAnthony R M Coates
Jul 7, 2007·American Journal of Respiratory and Critical Care Medicine·Anuran ChatterjeeJohn D Catravas
Dec 24, 2013·World Journal of Gastroenterology : WJG·Ko Eun LeeYoung Do Jung
May 7, 2014·Cell Stress & Chaperones·Stefan TukajMichael Kasperkiewicz
Jan 1, 2010·International Journal of Proteomics·Ho-Jae LeeKi-Baik Hahm
Mar 19, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jung M KimHyun C Jung
Feb 5, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anuran ChatterjeeJohn D Catravas
Mar 10, 2007·International Journal of Immunopathology and Pharmacology·G Di BonaventuraM Neri

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