Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries

Biochimica Et Biophysica Acta
Peng ZhongGuang Liang

Abstract

Increased oxidative stress and cardiac inflammation have been implicated in the pathogenesis of diabetic cardiomyopathy (DCM). We previously found that a novel chalcone derivative, L6H9, was able to reduce LPS-induced inflammatory response in macrophages. This study was designed to investigate its protective effects on DCM and the underlying mechanisms. H9C2 cells were cultured with DMEM containing 33 mmol/L of glucose in the presence or absence of L6H9. Pretreatment with L6H9 significantly reduced high glucose-induced inflammatory cytokine expression, ROS level increase, mitochondrial dysfunction, cell apoptosis, fibrosis, and hypertrophy in H9c2 cells, which may be mediated by NF-κB inhibition and Nrf2 activation. In mice with STZ-induced diabetes, oral administration of L6H9 at 20 mg/kg/day for 8 weeks significantly decreased the cardiac cytokine and ROS level, accompanied by decreasing cardiac apoptosis and hypertrophy, and, finally, improved histological abnormalities and fibrosis, without affecting the hyperglycemia. L6H9 also attenuated the diabetes-induced NF-κB activation and Nrf2 decrease in diabetic hearts. These results strongly suggest that L6H9 may have great therapeutic potential in the treatment of DCM via block...Continue Reading

References

Sep 6, 2002·Cardiovascular Toxicology·L Cai, Y J Kang
Oct 14, 2003·Cardiovascular Toxicology·Lu Cai, Y James Kang
Jun 26, 2004·Circulation Research·Min NianPeter Liu
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Oct 16, 2008·Mini Reviews in Medicinal Chemistry·C KontogiorgisD Hadjipavlou-Litina
Nov 7, 2009·Current Clinical Pharmacology·Daniela Ilieva Batovska, Iva Todorova Todorova
Feb 13, 2010·Annual Review of Physiology·Christopher P Baines
Feb 25, 2010·Reviews in Endocrine & Metabolic Disorders·Sihem Boudina, Evan Dale Abel
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Janet K Snell-BergeonDana Dabelea
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
Oct 23, 2010·Archives of Biochemistry and Biophysics·Mohamed M El-SeweidyOlfat G Shaker
May 5, 2011·Journal of Medicinal Chemistry·Vineet KumarSanjay V Malhotra
Jun 1, 2011·Heart Failure Reviews·Inês Falcão-Pires, Adelino F Leite-Moreira
Oct 13, 2011·Journal of Medicinal Chemistry·Jianzhang WuGuang Liang
Jun 19, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Masanori ObanaYasushi Fujio
Jul 31, 2012·Experimental Diabetes Research·Yingmei ZhangJun Ren
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
Nov 30, 2013·Mediators of Inflammation·O LorenzoJ Tuñón
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Jan 31, 2014·Diabetologia·Heiko Bugger, E Dale Abel

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Citations

Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi Yeong JeongDawon Kang
Sep 8, 2016·Proteomics. Clinical Applications·Donatus O OnwuliPedro Beltran-Alvarez
May 23, 2017·Nutrients·Rosanna MatteraRoberto Bei
Jul 7, 2017·Critical Reviews in Food Science and Nutrition·Lei ChenJianbo Xiao
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matheus de Freitas SilvaAndrea Tarozzi
Feb 13, 2016·Magnetic Resonance in Chemistry : MRC·Thrineshen MoodleyNeil A Koorbanally
Jan 27, 2018·Cell Death & Disease·Caroline Maria Oliveira VolpeJosé Augusto Nogueira-Machado
Dec 26, 2018·Journal of Drug Targeting·Dana ElkhalifaAshraf Khalil
Jul 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bin ZhangXiaobo Sun
Sep 14, 2019·Canadian Journal of Physiology and Pharmacology·Yun LiuFutian Tang
Nov 7, 2017·Oxidative Medicine and Cellular Longevity·Sandro SattaStephen J White
Nov 13, 2018·Frontiers in Physiology·Maria Consiglia TrottaClara Di Filippo
Feb 17, 2017·Aging and Disease·Hong ZhengLiang-Jun Yan
Apr 4, 2020·Current Pharmaceutical Design·Emília P T Leitão
Aug 28, 2021·Biomolecules·Hiba A JasimSatyajit D Sarker

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