Blockage of substance P-induced scratching behavior in rats by the intrathecal administration of inhibitory amino acid agonists.

Pharmacology, Biochemistry, and Behavior
C BeyerB R Komisaruk

Abstract

Intrathecal administration of 20 micrograms of substance P induced scratching behavior in most tested rats (80%). Scratching appeared in bouts of short latency and variable duration, intensity and frequency (range 1-60, mean number of scratching bouts in one hour test: 8.93 +/- 1.86). Intrathecal administration of glycine (400 micrograms but not 66 micrograms) significantly decreased the effect of substance P on this behavior. Taurine, in dosages equimolar to glycine, abolished the response to substance P at the high dose level (700 micrograms), but did not significantly affect it at the lower level (120 micrograms). The GABAA agonist, muscimol, abolished the effect of substance P at the 3 micrograms dose level, but the 0.5 microgram dose did not produce a significant effect. Baclofen, a GABAB agonist, was highly effective in significantly reducing the action of SP at 0.9 and 0.15 microgram; only two of 8 rats receiving the low dose of baclofen (0.15 microgram) exhibited scratching. The results suggest that the spinal inhibitory amino acids modulate nociceptive impulses generated by the action of substance P in dorsal horn neurons of the spinothalamic tract.

References

Apr 27, 1979·Brain Research·W Zieglgänsberger, I F Tulloch
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·V Chan-Palay, S L Palay
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Oct 15, 1978·European Journal of Pharmacology·P R Wilson, T L Yaksh
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Oct 24, 1975·Brain Research·K SaitoM Otsuka
Dec 1, 1975·The Journal of Comparative Neurology·B J McLaughlinJ Y Wu
Oct 27, 1987·European Journal of Pharmacology·D W BonhausJ O McNamara
Nov 3, 1986·Life Sciences·L A RobertsB R Komisaruk
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J Sawynok
Sep 2, 1985·Life Sciences·C BeyerB R Komisaruk
Aug 21, 1980·Nature·M R HanleyR Wade
Jun 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, J Donnerer
Aug 1, 1981·Neuropharmacology·A RackhamP L Wood
Aug 3, 1984·European Journal of Pharmacology·D L Hammond, E J Drower
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

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Citations

Mar 11, 2005·Archives of Physical Medicine and Rehabilitation·Djamel Ben SmailBernard Bussel
Feb 7, 2001·Arquivos de neuro-psiquiatria·J A D'AlmeidaT F Nogueira
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats

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