Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells.

Journal of Neuro-oncology
Jinhai GuJian Zhang

Abstract

Gliomas are the most common type of primary tumor in the human central nervous system. STAT3, a signal transducer and activator of transcription 3, is over expressed in gliomas. Its involvement in tumorgenesis can be attributed to its ability to induce cell proliferation and inhibit apoptosis. Double-stranded decoy oligodeoxynucleotides (ODNs) which correspond closely to the STAT3 response element within the c-fos promoter are a potential tool for inhibiting a variety of tumor cell growth. To investigate its therapeutic potential in malignant gliomas, a 15-mer double-stranded decoy ODN mimicking STAT3-specific cis-elements was transfected into two glioma cell lines, U251 and A172. The STAT3 decoy ODN treatment specifically blocked STAT3 signaling and subsequently inhibited U251 and A172 cell proliferation by inducing apoptosis and cell-cycle arrest. The ODN treatment also decreased transcription and translation of downstream STAT3 target genes including c-myc, cyclin D1 and bcl-xl in both cell lines. Thus, targeted blockade of the STAT3 signaling pathway with a decoy ODN is a potential anti-glioma therapeutic approach.

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Citations

Jul 15, 2011·Expert Opinion on Investigational Drugs·Arun K Mankan, Florian R Greten
Dec 7, 2013·Journal of Hematology & Oncology·Muhammad FurqanDelong Liu
Nov 13, 2015·International Journal of Cancer. Journal International Du Cancer·Kasturi Banerjee, Haluk Resat
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Jan 14, 2010·Journal of Molecular Neuroscience : MN·Fuxue ChenYonghua Ji
Jan 28, 2021·Cancers·Alexander OuAmy B Heimberger
Nov 21, 2008·Journal of Cell Science·Eric A Klein, Richard K Assoian
Jun 4, 2021·Immunotherapy·Lidia GattoAlba Ariela Brandes

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