PMID: 8584411Nov 1, 1995Paper

Blockers of volume-activated Cl- currents inhibit endothelial cell proliferation

Pflügers Archiv : European journal of physiology
T VoetsB Nilius

Abstract

Volume-activated Cl- currents (ICl,vol) and cell growth have been measured in cultured endothelial cells from bovine pulmonary artery (CPAE) in the absence and presence of compounds which block these currents. The anti-oestrogen drug tamoxifen, which efficiently arrests the growth of breast cancer cells (1), inhibits both ICl,vol and cell proliferation with IC50 of 3.8 and 4.8 micromol/l respectively.NPPB and quinine, which also block ICl,vol, inhibit the growth of CPAE cells as well. Current and cell growth were closely correlated under all these conditions. We conclude that ICl,vol might be involved in the control of endothelial cell growth and thus might be important for the modulation of vascularisation and vascular remodelling.

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Citations

Jun 8, 2001·Biochemical and Biophysical Research Communications·D TrouetJ Eggermont
Dec 20, 2005·The Journal of Membrane Biology·Karl Kunzelmann
Apr 12, 2008·Purinergic Signalling·Ravshan Z Sabirov, Yasunobu Okada
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