Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis.

Journal of the American Society of Nephrology : JASN
A BenigniG Remuzzi

Abstract

Angiotensin-converting enzyme inhibitors restore size-selective dysfunction of the glomerular barrier in experimental animals and humans with proteinuric nephropathies, although the structural and molecular determinants of such an effect are not completely understood. This study used an accelerated model of experimental nephrosis to assess nephrin gene and protein expression in the kidney and the possible modulating effect of drugs that block angiotensin II (AII) synthesis/activity. Passive Heymann nephritis (PHN) and control animals were studied at day 7, month 4, and month 8. Additional PHN rats were treated with lisinopril or AII receptor blocker L-158,809 and studied at 8 mo. Lisinopril and L-158,809 controlled BP, prevented proteinuria, and protected PHN animals from renal injury. An intense signal of nephrin mRNA was detected in glomeruli of control animals mainly restricted to podocytes. In PHN rats, nephrin staining progressively and remarkably decreased with time. Lisinopril and L-158,809 fully prevented the decrease in nephrin transcripts to levels comparable to those of control rats. Consistent with nephrin mRNA expression, immunostaining of the protein showed a progressive decrease in kidneys from PHN rats that was ...Continue Reading

References

Feb 1, 1994·Kidney International·A Remuzzi, G Remuzzi
May 1, 1996·Journal of the American Society of Nephrology : JASN·R LapinskiG Remuzzi
Jan 1, 1997·Kidney International·G RemuzziA Benigni
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
May 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P N FurnessJ H Pringle
Sep 17, 1999·The American Journal of Pathology·H AholaH Holthöfer
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·K Tryggvason
Nov 7, 1999·The American Journal of Pathology·H HolthöferD Kerjaschki
Nov 30, 1999·Science·I Wickelgren

❮ Previous
Next ❯

Citations

Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Huaiping YuanDavid J Salant
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Olga BeltchevaKarl Tryggvason
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Jean-Louis MichaudChris R J Kennedy
May 23, 2003·Journal of the American Society of Nephrology : JASN·Carla ZojaGiuseppe Remuzzi
Oct 16, 2010·The Journal of Biological Chemistry·Hua LiuRadhakrishna Baliga
Mar 29, 2002·Kidney International·Marina Noris, Giuseppe Remuzzi
Apr 23, 2002·Kidney International·Carla ZojaGiuseppe Remuzzi
Sep 12, 2002·Seminars in Nephrology·Mark E CooperGeoffrey Boner
Dec 11, 2002·Kidney International·Zhu-Zhu ChengHarry Holthöfer
Mar 13, 2003·Kidney International·Mauro Abbate, Giuseppe Remuzzi
Nov 2, 2002·Kidney International. Supplement·Hernan Rincon-CholesHanna E Abboud
Jul 9, 2003·Kidney International·Juhani LahdenperäKarl Tryggvason
Apr 26, 2006·Experimental Biology and Medicine·Yan XingNa Guan
Aug 22, 2003·Journal of Internal Medicine·K Tryggvason, E Pettersson
Jul 16, 2003·The American Journal of the Medical Sciences·Ursula C BrewsterMark A Perazella
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Robyn G LanghamRichard E Gilbert
Feb 19, 2004·The American Journal of Medicine·Ursula C Brewster, Mark A Perazella
May 20, 2004·Kidney International·Ariela BenigniGiuseppe Remuzzi
Oct 7, 2004·Biochemical and Biophysical Research Communications·Liliana SchaeferJosef Pfeilschifter
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Zemin CaoMark E Cooper
Mar 13, 2003·Kidney International·Kim Pettersson-FernholmUNKNOWN FinnDiane Study Group
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Masaomi NangakuWilliam G Couser
Dec 19, 2003·Expert Opinion on Drug Safety·Ursula C Brewster, Mark A Perazella
Jun 9, 2005·American Journal of Physiology. Renal Physiology·Farid NakhoulZaid Abassi
Nov 4, 2005·Journal of the American Society of Nephrology : JASN·Liming WangRobert F Spurney
May 11, 2005·Kidney International·Takeshi NakatsueHiroshi Kawachi
Sep 15, 2005·American Journal of Physiology. Renal Physiology·Andrey V CybulskyDavid J Salant
Jan 18, 2006·Annual Review of Medicine·Raymond C Harris, Eric G Neilson
Dec 13, 2005·Kidney International. Supplement·Manuel Praga
Apr 25, 2006·Current Biology : CB·Kay-Dietrich WagnerAndreas Schedl
Aug 8, 2006·Nephrology·Hiroshi KawachiFujio Shimizu
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Gema Fernandez-JuárezJosé Luño
Jul 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnes B Fogo
Jan 8, 2008·Current Hypertension Reports·Jochen Reiser, Peter Mundel
Dec 4, 2001·Annals of Medicine·H JalankoC Holmberg
Nov 27, 2007·Expert Opinion on Pharmacotherapy·Piero RuggenentiGiuseppe Remuzzi
Dec 21, 2007·American Journal of Physiology. Renal Physiology·Farid NakhoulZaid Abassi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.