Blocking costimulatory pathways: prospects for inducing transplantation tolerance

Immunotherapy
Bert VerbinnenJan L Ceuppens

Abstract

Tolerance induction to alloantigens is a major challenge in transplant immunology. Whereas conventional immunosuppression inhibits the immune system in a nonspecific way, thereby also undermining an appropriate immune response towards potentially harmful infectious organisms, tolerance in a transplantation setting is restricted to alloantigens, while protective immunity is preserved. Moreover, tolerance implies an immunological status that is preserved after withdrawal of the tolerance-inducing therapy. Among the most promising strategies to induce immunological tolerance are costimulation blockade and establishment of mixed chimerism. Despite significant advances, we still know little about the mechanisms responsible for such tolerance. In this article, we discuss tolerance induction to transplantation antigens by costimulation blockade.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L A TurkaD Gordon
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Apr 24, 1987·Cell·J W KapplerP Marrack
Mar 1, 1995·The Journal of Experimental Medicine·B RochaA A Freitas
Jun 27, 1994·Transplantation·T C PearsonC P Larsen
Jun 13, 1996·Nature·S M AlamN R Gascoigne
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·W W HancockL A Turka
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Nov 22, 1997·Current Opinion in Immunology·C P Larsen, T C Pearson
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·U G SvendsenG Petterson
Feb 13, 2001·Annual Review of Medicine·T Wekerle, M Sykes
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F SebilleJ P Soulillou
Mar 5, 2002·Nature Medicine·Patrick AndréDenisa D Wagner
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KurtzM Sykes
Sep 17, 2002·Cell Death and Differentiation·F FallarinoP Puccetti
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Oct 31, 2002·Nature Immunology·Erik B Finger, Jeffrey A Bluestone
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Dec 10, 2002·Annual Review of Immunology·Ronald H Schwartz
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xueli YuanMohamed H Sayegh
Mar 18, 2003·Transplantation·Krista G HaanstraMargreet Jonker
Jul 17, 2003·The Journal of Clinical Investigation·Hiroshi HaradaMohamed H Sayegh
Sep 4, 2003·Circulation·William S Weintraub, Viola Vaccarino
Sep 17, 2003·Nature Reviews. Immunology·Michael Croft

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Citations

Mar 31, 2015·European Journal of Pharmacology·James McDaidPaulo N Martins
Jan 26, 2013·European Journal of Immunology·Isabel VogelJan L Ceuppens
Oct 20, 2018·Expert Opinion on Drug Discovery·Russell CostelloJames McDaid
Sep 19, 2019·Brain : a Journal of Neurology·Shen LiPiotr Walczak

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